| Hydroperoxide lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.99.- | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| |||||||||
Hydroperoxide lyases areenzymes that catalyze the cleavage ofC-C bonds in the hydroperoxides offatty acids. They belong to thecytochrome P450 enzyme family (CYP74C and CYP74B).[1]
Polyunsaturated fatty acids such aslinolenic andlinoleic acids are susceptible to formation ofhydroperoxides upon contact with oxygen in air. Hydroperoxides are highly reactivefunctional groups since they contain an oxidant (O-O bond) adjacent to a reductant (C-H bonds). When flanked by olefins, the hydroperoxides can be induced to rearrange to give thehemiacetal. It is this reaction that is catalyzed by hydroperoxide lyases. The resulting aldehydes are notable as fragrances,green leaf volatiles, and antifeedants.[2]
