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HIVEP3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

HIVEP3
Identifiers
AliasesHIVEP3, Hivep3, 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Rc, Schnurri-3, Shn3, Zas3, ZNF40C, human immunodeficiency virus type I enhancer binding protein 3, Kappa Recognition Component (Krc), KRC, HIVEP zinc finger 3
External IDsOMIM:606649;MGI:106589;HomoloGene:7803;GeneCards:HIVEP3;OMA:HIVEP3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HIVEP3
Genomic location for HIVEP3
Band1p34.2Start41,506,365bp[1]
End42,035,925bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for HIVEP3
Genomic location for HIVEP3
Band4|4 D2.1Start119,590,981bp[2]
End119,995,242bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • endothelial cell

  • Brodmann area 23

  • cartilage tissue

  • parietal pleura

  • primary visual cortex

  • granulocyte

  • middle temporal gyrus

  • entorhinal cortex

  • germinal epithelium
Top expressed in
  • gastrula

  • medial geniculate nucleus

  • Rostral migratory stream

  • subiculum

  • medial dorsal nucleus

  • lateral geniculate nucleus

  • substantia nigra

  • trigeminal ganglion

  • anterior amygdaloid area

  • submandibular gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

59269

16656

Ensembl

ENSG00000127124

ENSMUSG00000028634

UniProt

Q5T1R4

A2A884

RefSeq (mRNA)

NM_001127714
NM_024503

NM_010657

RefSeq (protein)

NP_001121186
NP_078779

NP_034787

Location (UCSC)Chr 1: 41.51 – 42.04 MbChr 4: 119.59 – 120 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor HIVEP3 is aprotein that in humans is encoded by theHIVEP3gene.[5][6]

Function

[edit]

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][6]

It regulatesosteoblasts.[7]

Interactions

[edit]

HIVEP3 has been shown tointeract withTRAF1[8] andTRAF2.[8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000127124 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028634 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Hicar MD, Liu Y, Allen CE, Wu LC (January 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2".Genomics.71 (1):89–100.doi:10.1006/geno.2000.6425.PMID 11161801.
  6. ^ab"Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3".
  7. ^Glimcher LH, Jones DC, Wein MN (November 2007). "Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3".Annals of the New York Academy of Sciences.1116 (1):174–181.Bibcode:2007NYASA1116..174G.doi:10.1196/annals.1402.044.PMID 18083927.S2CID 25260678.
  8. ^abOukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (January 2002)."A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2".Molecular Cell.9 (1):121–131.doi:10.1016/S1097-2765(01)00434-8.PMID 11804591.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous
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