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HIVEP1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

HIVEP1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1BBO,4ZNF

Identifiers

Aliases

HIVEP1, CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A, human immunodeficiency virus type I enhancer binding protein 1, HIVEP zinc finger 1

External IDs

OMIM:194540;MGI:96100;HomoloGene:1596;GeneCards:HIVEP1;OMA:HIVEP1 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p24.1	Start	12,008,762bp^[1]
Band	6p24.1	End	12,164,999bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 A4\|13 20.72 cM	Start	42,205,497bp^[2]
Band	13 A4\|13 20.72 cM	End	42,346,013bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

cartilage tissue

sural nerve

epithelium of colon

superficial temporal artery

jejunal mucosa

seminal vesicula

oral cavity

right lobe of liver

caput epididymis

Top expressed in

zygote

genital tubercle

secondary oocyte

primary oocyte

tail of embryo

medial dorsal nucleus

lateral geniculate nucleus

primary motor cortex

habenula

medial geniculate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	cytoplasm mitochondrion nucleus nucleoplasm nuclear body
Biological process	multicellular organism development regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II signal transduction transcription, DNA-templated BMP signaling pathway positive regulation of transcription by RNA polymerase II
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3096


110521

Ensembl


ENSG00000095951


ENSMUSG00000021366

UniProt


P15822


Q03172

RefSeq (mRNA)


NM_002114


NM_007772

RefSeq (protein)


NP_002105


NP_031798

Location (UCSC)

Chr 6: 12.01 – 12.16 Mb

Chr 13: 42.21 – 42.35 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger protein 40 is aprotein that in humans is encoded by theHIVEP1gene.^[5]^[6]

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000095951 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000021366 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ (Jul 1991). "Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24".Genomics.9 (4):758–61.doi:10.1016/0888-7543(91)90371-K.PMID 2037300.
^^a ^b"Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1".

Omichinski JG, Clore GM, Robien M, et al. (1992). "High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1".Biochemistry.31 (16):3907–17.doi:10.1021/bi00131a004.PMID 1567844.
Nakamura T, Donovan DM, Hamada K, et al. (1990)."Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes".Mol. Cell. Biol.10 (7):3700–8.doi:10.1128/mcb.10.7.3700.PMC 360816.PMID 1694016.
Muchardt C, Seeler JS, Nirula A, et al. (1992)."Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products".J. Virol.66 (1):244–50.doi:10.1128/JVI.66.1.244-250.1992.PMC 238281.PMID 1727488.
Fan CM, Maniatis T (1990)."A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence".Genes Dev.4 (1):29–42.doi:10.1101/gad.4.1.29.PMID 2106471.
Baldwin AS, LeClair KP, Singh H, Sharp PA (1990)."A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes".Mol. Cell. Biol.10 (4):1406–14.doi:10.1128/mcb.10.4.1406.PMC 362243.PMID 2108316.
Omichinski JG, Clore GM, Appella E, et al. (1991). "High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution".Biochemistry.29 (40):9324–34.doi:10.1021/bi00492a004.PMID 2248949.
Maekawa T, Sakura H, Sudo T, Ishii S (1989)."Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1".J. Biol. Chem.264 (25):14591–3.doi:10.1016/S0021-9258(18)63733-0.PMID 2504707.
Otsuka M, Fujita M, Aoki T, et al. (1995). "Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B".J. Med. Chem.38 (17):3264–70.doi:10.1021/jm00017a011.PMID 7650680.
Seeler JS, Muchardt C, Suessle A, Gaynor RB (1994)."Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression".J. Virol.68 (2):1002–9.doi:10.1128/JVI.68.2.1002-1009.1994.PMC 236538.PMID 8289330.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004)."Functional proteomics mapping of a human signaling pathway".Genome Res.14 (7):1324–32.doi:10.1101/gr.2334104.PMC 442148.PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proc. Natl. Acad. Sci. U.S.A.101 (33):12130–5.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC 514446.PMID 15302935.
Wissmüller S, Kosian T, Wolf M, et al. (2006)."The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors".Nucleic Acids Res.34 (6):1735–44.doi:10.1093/nar/gkl105.PMC 1421504.PMID 16582099.
Lim J, Hao T, Shaw C, et al. (2006)."A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration".Cell.125 (4):801–14.doi:10.1016/j.cell.2006.03.032.PMID 16713569.S2CID 13709685.

v t e PDB gallery
1bbo: HIGH-RESOLUTION SOLUTION STRUCTURE OF THE DOUBLE CYS2HIS2 ZINC FINGER FROM THE HUMAN ENHANCER BINDING PROTEIN MBP-1 3znf: HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION 4znf*: HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION

External links

[edit]

HIVEP1+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	BHLH 2 3 9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see alsotranscription factor/coregulator deficiencies

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