Inanatomy, thegerminal matrix is a highly cellular and highlyvascularized region in thebrain out from whichcells migrate duringbrain development. The germinal matrix is the source of bothneurons andglial cells and is most active between 8 and 28 weeksgestation. It is a fragile portion of thebrain that may be damaged leading to agerminal matrix hemorrhage (grade 1intraventricular hemorrhage).
Location/anatomy: The germinal matrix is next to the lateral ventricles (the "inside" of the brain).
Function/physiology: Neurons and glia migrate radially outward from the germinal matrix towards the cerebral cortex. For more information, see the associated articles on neuronal migration and corticogenesis.[1][2][3]
Dysfunction/pathophysiology: in prenatology/neonatology, intraventricular hemorrhages occur starting in the germinal matrix due to the lack of structural integrity there. Intraventricular hemorrhages are a common and harmful issue in children born prematurely.[4]
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