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Protein wntless homolog

From Wikipedia, the free encyclopedia
(Redirected fromGPR177)
Protein-coding gene in the species Homo sapiens

WLS
Identifiers
AliasesWLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator, ZKS
External IDsOMIM:611514;MGI:1915401;HomoloGene:11779;GeneCards:WLS;OMA:WLS - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for WLS
Genomic location for WLS
Band1p31.3Start68,098,473bp[1]
End68,233,120bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for WLS
Genomic location for WLS
Band3|3 H4Start159,545,309bp[2]
End159,644,300bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • Epithelium of choroid plexus

  • retinal pigment epithelium

  • corpus epididymis

  • gastric mucosa

  • islet of Langerhans

  • gallbladder

  • optic nerve

  • endothelial cell

  • bronchial epithelial cell
Top expressed in
  • calvaria

  • molar

  • left lung lobe

  • olfactory epithelium

  • pineal gland

  • choroid plexus of fourth ventricle

  • maxillary prominence

  • right kidney

  • corneal stroma

  • seminal vesicula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79971

68151

Ensembl

ENSG00000116729

ENSMUSG00000028173

UniProt

Q5T9L3

Q6DID7

RefSeq (mRNA)

NM_001002292
NM_001193334
NM_024911

NM_026582
NM_001356349
NM_001356350

RefSeq (protein)

NP_001002292
NP_001180263
NP_079187

NP_080858
NP_001343278
NP_001343279

Location (UCSC)Chr 1: 68.1 – 68.23 MbChr 3: 159.55 – 159.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein wntless homolog, commonly known asWntless, is encoded in humans by theWLSgene .[5] Wntless is a receptor forWnt proteins in Wnt-secreting cells.[6]

Wntless was shown to be a cargo for theretromer complex.[6] It has been found essential for hair follicle induction.[7]

Ahomozygousmissense mutation in theWLS gene was identified inZaki syndrome.[8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000116729Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028173Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"WLS - Protein wntless homolog - Homo sapiens (Human) - WLS gene & protein".www.uniprot.org. Retrieved30 May 2022.
  6. ^abEaton S (January 2008)."Retromer retrieves wntless".Developmental Cell.14 (1):4–6.doi:10.1016/j.devcel.2007.12.014.PMID 18194646.
  7. ^Fu J, Hsu W (April 2013)."Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis".The Journal of Investigative Dermatology.133 (4):890–898.doi:10.1038/jid.2012.407.PMC 3594635.PMID 23190887.
  8. ^Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, et al. (September 2021)."A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion".The New England Journal of Medicine.385 (14):1292–1301.doi:10.1056/NEJMoa2033911.PMC 9017221.PMID 34587386.

Further reading

[edit]

See also

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This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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