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GPR160

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GPR160

Identifiers

Aliases

GPR160, GPCR1, GPCR150, G protein-coupled receptor 160

External IDs

MGI:1919112;HomoloGene:8659;GeneCards:GPR160;OMA:GPR160 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q26.2	Start	170,037,995bp^[1]
Band	3q26.2	End	170,085,392bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 A3	Start	30,910,099bp^[2]
Band	3\|3 A3	End	30,951,341bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of ileum

mucosa of sigmoid colon

rectum

corpus epididymis

duodenum

bone marrow

jejunal mucosa

bone marrow cells

mucosa of transverse colon

trabecular bone

Top expressed in

spermatocyte

spermatid

seminiferous tubule

lens

jejunum

epithelium of lens

right kidney

granulocyte

duodenum

skin of abdomen

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity
Cellular component	integral component of membrane receptor complex membrane plasma membrane
Biological process	G protein-coupled receptor signaling pathway signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


26996


71862

Ensembl


ENSG00000173890


ENSMUSG00000037661

UniProt


Q9UJ42


Q3U3F9

RefSeq (mRNA)


NM_014373

NM_001134385 NM_001134386 NM_001286994 NM_001286995 NM_001286996
NM_027965 NM_001357144

RefSeq (protein)


NP_055188

NP_001127857 NP_001127858 NP_001273923 NP_001273924 NP_001273925
NP_082241 NP_001344073

Location (UCSC)

Chr 3: 170.04 – 170.09 Mb

Chr 3: 30.91 – 30.95 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 160 is aprotein that in humans is encoded by theGPR160gene.^[5]^[6] It has been identified as the receptor forCocaine- and amphetamine-regulated transcript, also known as CART.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000173890 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000037661 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence".FEBS Letters.520 (1–3):97–101.Bibcode:2002FEBSL.520...97T.doi:10.1016/S0014-5793(02)02775-8.PMID 12044878.S2CID 7116392.
^"Entrez Gene: GPR160 G protein-coupled receptor 160".
^Yosten GL, Harada CM, Haddock C, Giancotti LA, Kolar GR, Patel R, et al. (May 2020)."GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents".The Journal of Clinical Investigation.130 (5):2587–2592.doi:10.1172/JCI133270.PMC 7190928.PMID 31999650.

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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