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GPR135

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GPR135

Identifiers

Aliases

GPR135, HUMNPIIY20, G protein-coupled receptor 135

External IDs

OMIM:607970;MGI:2676315;HomoloGene:11211;GeneCards:GPR135;OMA:GPR135 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q23.1	Start	59,429,022bp^[1]
Band	14q23.1	End	59,465,380bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 C3	Start	72,114,750bp^[2]
Band	12\|12 C3	End	72,117,899bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left testis

right testis

sperm

testicle

right uterine tube

buccal mucosa cell

right coronary artery

ventricular zone

left coronary artery

popliteal artery

Top expressed in

substantia nigra

Region I of hippocampus proper

ventromedial nucleus

paraventricular nucleus of hypothalamus

dorsomedial hypothalamic nucleus

arcuate nucleus

lateral hypothalamus

fossa

lateral septal nucleus

anterior amygdaloid area

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity protein binding arrestin family protein binding
Cellular component	integral component of membrane membrane plasma membrane endosome endosome membrane
Biological process	G protein-coupled receptor signaling pathway signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


64582


238252

Ensembl


ENSG00000181619


ENSMUSG00000043398

UniProt


Q8IZ08


Q7TQP2

RefSeq (mRNA)


NM_022571


NM_181752

RefSeq (protein)


NP_072093


NP_861417

Location (UCSC)

Chr 14: 59.43 – 59.47 Mb

Chr 12: 72.11 – 72.12 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 135 is aprotein that in humans is encoded by theGPR135gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000181619 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000043398 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (Nov 2003)."Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives".FEBS Lett.554 (3):381–8.doi:10.1016/S0014-5793(03)01196-7.PMID 14623098.S2CID 11563502.
^"Entrez Gene: GPR135 G protein-coupled receptor 135".

Kunz D, Gerard NP, Gerard C (1992)."The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog".J. Biol. Chem.267 (13):9101–6.doi:10.1016/S0021-9258(19)50394-5.PMID 1374385.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Vassilatis DK, Hohmann JG, Zeng H, et al. (2003)."The G protein-coupled receptor repertoires of human and mouse".Proc. Natl. Acad. Sci. U.S.A.100 (8):4903–8.Bibcode:2003PNAS..100.4903V.doi:10.1073/pnas.0230374100.PMC 153653.PMID 12679517.
Vanti WB, Nguyen T, Cheng R, et al. (2003). "Novel human G-protein-coupled receptors".Biochem. Biophys. Res. Commun.305 (1):67–71.doi:10.1016/S0006-291X(03)00709-5.PMID 12732197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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