Gamma-aminobutyric acid receptor subunit pi is aprotein that in humans is encoded by theGABRPgene.[5][6]
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.[6]
Zafrakas M, Chorovicer M, Klaman I, et al. (2007). "Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue".Int. J. Cancer.118 (6):1453–1459.doi:10.1002/ijc.21517.PMID16187283.S2CID21983109.
Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes".J. Neurovirol.9 (3):358–371.doi:10.1080/13550280390201119.PMID12775419.S2CID22016092.
Neelands TR, Macdonald RL (1999). "Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors".Mol. Pharmacol.56 (3):598–610.doi:10.1124/mol.56.3.598.PMID10462548.
