Thefree fraction is a parameter inpharmacokinetics andreceptor-ligand kinetics.One speaks of two different free fractions:

• Plasma free fraction, previously referred to as ƒ₁,^[1] is now referred to as ƒ_P according to consensusnomenclature.^[2]
• Tissue free fraction (ƒ_ND), previously referred to as ƒ₂^[1]

Theplasma free fraction is the fraction of theligand at equilibrium inblood plasma that is not bound toplasma proteins.

• Binding potential

• Milak MS, Severance AJ, Ogden RT, Prabhakaran J, Kumar JS, Majo VJ, Mann JJ, Parsey RV (2008)."Modeling Considerations for 11C-CUMI-101, an Agonist Radiotracer for Imaging Serotonin 1A Receptor In Vivo with PET".J. Nucl. Med.49 (4):587–596.doi:10.2967/jnumed.107.046540.PMC 3580231.PMID 18344443.

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