Born inMaipú, Mendoza, Pérez began his career inDeportivo Maipú, like his father, and started his professional playing career withGodoy Cruz, where he wrote his name into club history by scoring a fifth-minute goal in the 1–1 draw withBelgrano on 9 September 2006. This was the first goal ever scored by Godoy Cruz in the Argentine first division. In total, he scored 12 goals in his career at Godoy Cruz, most coming from penalties. In 2007, Pérez joinedEstudiantes de La Plata, where he finished as runner-up with the team in the2008 Copa Sudamericana. He was then a first team regular in the team that won the2009 Copa Libertadores.
On 8 June 2011, Pérez signed a five-year contract with Portuguese clubBenfica for a fee rumored to be around €5.5 million for his full rights from Estudiantes.[4] After a serious knee injury sustained in theChampions League qualifiers, Pérez was loaned back to Estudiantes for six months on 9 February 2012.[5]
On 27 July 2012, at theEusébio Cup, Pérez scored a long-range goal againstReal Madrid from a tight angle to complete a 5–2 win.[6]
In the2013–14 season, his influence was further increased after the departure of Matić toChelsea on 15 January 2014, becoming a vital piece in Benfica's domestictreble (Primeira Liga,Taça de Portugal andTaça da Liga) and their second consecutiveEuropa League Final. Pérez, however, was not present in the eventual loss on penalties (4–2) toSevilla in the final, having picked up a suspension in the semi-final againstJuventus on 1 May 2014.[8][9] His performances attracted attention from other clubs,[10] while Benfica managerJorge Jesus named Pérez his side's most difficult player to replace and the "brain" of the team.[11][12] On 6 July 2014, Pérez won thePlayer of the Year award.[13]
On 2 January 2015, SpanishLa Liga clubValencia CF signed Pérez[14][15] for a transfer fee of €25 million,[16] the tenth-highest ever fee for an Argentine player.[17] On 4 January, he debuted for Valencia in a home win over Real Madrid (2–1) in La Liga.[18]
On 29 June 2017, Pérez returned to Argentina and signed forRiver Plate.[19]
Ahead of aCopa Libertadores match on 19 May 2021, River Plate announced that over twenty players, including all four rosteredgoalkeepers, would miss the match due to aCOVID-19 outbreak within the squad. With no substitutes, the injured Pérez volunteered to play in goal for the entirety of the match against Colombian sideIndependiente Santa Fe in which River Plate won 2–1.[20] Pérez made a number of key saves and was awarded with the man of the match for his performance.[21][22] On 21 April 2021, Pérez extended his contract until December 2023.[23]
In May 2018, Pérez was named in Argentina's preliminary squad for the2018 FIFA World Cup,[30] but did not make the final list.[31] However, on 9 June 2018, he was called up as a replacement for the injuredManuel Lanzini.[32]
^"Comunicado" [Announcement](PDF).S.L. Benfica (in Portuguese).CMVM. 29 December 2014. Archived fromthe original(PDF) on 29 December 2014. Retrieved29 December 2014.