Edwin Goldmann | |
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| Born | (1862-11-12)12 November 1862 |
| Died | 12 August 1913(1913-08-12) (aged 50) Freiburg im Breisgau, Germany |
| Scientific career | |
| Academic advisors | Paul Ehrlich |
Edwin Goldmann (12 November 1862 – 12 August 1913) was a biomedical researcher andsurgeon most famous for his contributions in first characterizing theblood–brain barrier.[1]
Goldmann's mentor,Paul Ehrlich, was studyingstaining in hisbacteriological studies by injectinganiline dyes in several species of animal. While most of the anatomy stained equally well, the brain tissue exhibited less staining in many species. Goldmann discovered that when the dye (namely,trypan blue) was injected directly into thecentral nervous system instead of into the otherorgans, the brain would stain equally well as other organs — but the stain would not travel to the rest of the body.
This suggested the presence of a compartmentalization between thecerebrospinal fluid and thevasculature of the rest of the body. This barrier was first hypothesized by aBerlin physician,Max Lewandowsky, in 1900 (prior to Goldmann's empirical evidence).[1]
Edwin Goldmann died from liver cancer inFreiburg on 13 August 1913.[2]
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