 | |
| Clinical data | |
|---|---|
| Trade names | Humorsol |
| Routes of administration | Topical (ophthalmic solution) |
| ATC code | |
| Identifiers | |
| |
| CAS Number |
|
| PubChemCID | |
| DrugBank |
|
| ChemSpider |
|
| UNII | |
| KEGG |
|
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.000.274 |
| Chemical and physical data | |
| Formula | C32H52Br2N4O4 |
| Molar mass | 716.600 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
 N Y (what is this?) (verify) | |
Demecarium bromide, trade nameHumorsol, is acarbamateparasympathomimetic drug that acts as anacetylcholinesterase inhibitor, and is used as aglaucoma medication. It is applied directly to the eye in order to reduce elevatedintraocular pressure associated withglaucoma.[1]
Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).[2] As demecarium reversibly inhibitscholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such ascarbachol.[3]
Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,[4] is no longer available,[3] although solutions of demecarium can becompounded.[5]
When administered with a topicalcorticosteroid, demecarium can delay the onset ofprimary glaucoma in dogs.[3] High doses of demecarium may causeorganophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.[3]