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| Names | |
|---|---|
| Preferred IUPAC name Diethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | |
| Other names 4-(2,1,3-Benzoxadiazol-7-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
| UNII | |
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| Properties | |
| C19H21N3O5 | |
| Molar mass | 371.393 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Darodipine is an experimentalcalcium channel blocker that based onanimal models may reduce neuronal cytoskeletal alterations during aging and inneurodegenerative disorders. Studies performed on rats have shown darodipine to have an effect on brain serotonergic systems. Darodipine increased the 5-HIAA/5-HT ratio within various parts of thebrain.[1] Darodipine has also been shown to impair memory and learning processes on mice.[2]
The longterm effect of darodipine was tested in the rats and it shows that there is no significant change in their body and brain weight values but, there is a significant change in their alkaline phosphate reactive capillary profile values.Alkaline phosphate enzymes plays an important role in the functioning of the cerebral capillary activities.[3] The effect of darodipine onplasma concentration was also tested on a group of healthy male human volunteers. The result showed that darodipine resulted in the change in heart rate anddiastolic blood pressure which is related to the plasma concentration.[4]
Darodipine (50–500 nM), the sensitivity of DMPO‐COO.− adduct decreased by more than that of the DMPO‐OH adduct and the concentration-dependent drop in signal intensity. It has additional preventive effects, because of its calcium antagonistics, against free-radical mediated electrophysiological alterations; it is likely because of the trapping of such radical molecules.
