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| Clinical data | |
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| Other names | 6-Fluoro-16-methylene-17α-acetoxy-δ6-retroprogesterone; 6-Fluoro-16-methylene-17α-hydroxy-9β,10α-pregna-4,6-diene-3,20-dione 17α-acetate; 6-Fluoro-16-methylene-3,20-dioxo-9β,10α-pregna-4,6-dien-17α-yl acetate |
| Routes of administration | By mouth |
| Drug class | Progestin;Progestogen |
| Identifiers | |
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| CAS Number | |
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| Chemical and physical data | |
| Formula | C24H29FO4 |
| Molar mass | 400.490 g·mol−1 |
| 3D model (JSmol) | |
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DU-41165, also known as6-fluoro-16-methylene-17α-acetoxy-δ6-retroprogesterone, is aprogestin which was developed byPhilips-Duphar in the 1970s and was never marketed.[1][2] It is a combinedderivative of17α-hydroxyprogesterone andretroprogesterone.[1][2] The drug shows extremely highpotency as a progestogen in animals.[1] It has been found to possess 158% of therelative binding affinity ofpromegestone for theprogesterone receptor expressed in rat uterus (relative to 74% for the closely related progestinDU-41164).[1] DU-41165 also showed 28% of the affinity ofRU-28362 for theglucocorticoid receptor expressed in ratliver, but no affinity for themineralocorticoid receptor expressed in ratkidney (<0.003% of that ofRU-26752).[1] The drug showed noandrogenic,anabolic, orestrogenic activity in animals, but did show someantiandrogenic andglucocorticoid activity at high doses.[1] Although highly potent in animals, DU-41165 produced little or no progestogenic effect at dosages of 50 and 200 μg/day in women, suggesting major species differences.[1] DU-41165 has been studied as a potentialphotoaffinity label for the progesterone receptor.[1]
