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DHRS1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

DHRS1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2QQ5

Identifiers

Aliases

DHRS1, SDR19C1, dehydrogenase/reductase (SDR family) member 1, dehydrogenase/reductase 1

External IDs

OMIM:610410;MGI:1196314;HomoloGene:41696;GeneCards:DHRS1;OMA:DHRS1 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q12	Start	24,290,598bp^[1]
Band	14q12	End	24,299,780bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 C3\|14 28.19 cM	Start	55,976,477bp^[2]
Band	14 C3\|14 28.19 cM	End	55,983,147bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

duodenum

skin of leg

skin of abdomen

mucosa of transverse colon

vagina

minor salivary glands

spleen

olfactory zone of nasal mucosa

ectocervix

Top expressed in

ciliary body

duodenum

iris

right kidney

epithelium of small intestine

zygote

granulocyte

left lobe of liver

choroid plexus of fourth ventricle

More reference expression data

BioGPS


More reference expression data

Orthologs

Species

Human

Mouse

Entrez


115817


52585

Ensembl


ENSG00000157379 ENSG00000284868


ENSMUSG00000002332

UniProt


Q96LJ7


Q99L04

RefSeq (mRNA)


NM_001136050 NM_138452


NM_026819

RefSeq (protein)


NP_001129522 NP_612461


NP_081095

Location (UCSC)

Chr 14: 24.29 – 24.3 Mb

Chr 14: 55.98 – 55.98 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Dehydrogenase/reductase SDR family member 1, also known asShort chain dehydrogenase/reductase family 19C member 1 is anenzyme that in humans is encoded by theDHRS1gene located onchromosome 14.^[5]^[6]^[7]

Structure

[edit]

The DHRS1 gene is located on the chromosome 14q21.3 region and contains 9exons. It encodes a 314-amino-acid, 33-kDa protein that is thought to be located to theendoplasmic reticulum and themitochondrial inner membrane inside the cell.

Function

[edit]

The DHRS1 protein is thought to haveoxidoreductase activity based on sequence similarity and conservedcatalytic sites with other short-chain oxidoreductase enzymes. The enzyme is found to be expressed in the fetalbrain.^[8]

Interactions

[edit]

The DHRS1 protein is thought to interact with the protein phospholipid scrambase 1 (PLSCR1).^[9]

References

[edit]

^^a ^b ^cENSG00000284868 GRCh38: Ensembl release 89: ENSG00000157379, ENSG00000284868 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000002332 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, et al. (Aug 2002). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain".Mol Biol Rep.28 (4):193–8.doi:10.1023/A:1015722001960.PMID 12153138.S2CID 29552121.
^Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009)."The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative".Chem Biol Interact.178 (1–3):94–8.Bibcode:2009CBI...178...94P.doi:10.1016/j.cbi.2008.10.040.PMC 2896744.PMID 19027726.
^"Entrez Gene: DHRS1 dehydrogenase/reductase (SDR family) member 1".
^Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, et al. (2001). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain".Mol. Biol. Rep.28 (4):193–8.doi:10.1023/A:1015722001960.PMID 12153138.S2CID 29552121.
^"IntAct Portal".

Hartley JL, Temple GF, Brasch MA (2001)."DNA Cloning Using In Vitro Site-Specific Recombination".Genome Res.10 (11):1788–95.doi:10.1101/gr.143000.PMC 310948.PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (2001)."Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs".Genome Res.11 (3):422–35.doi:10.1101/gr.GR1547R.PMC 311072.PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001)."Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing".EMBO Rep.1 (3):287–92.doi:10.1093/embo-reports/kvd058.PMC 1083732.PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (2004)."From ORFeome to Biology: A Functional Genomics Pipeline".Genome Res.14 (10B):2136–44.doi:10.1101/gr.2576704.PMC 528930.PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, Del Val C, Arlt D, Hahne F, et al. (2006)."The LIFEdb database in 2006".Nucleic Acids Res.34 (Database issue): D415–8.doi:10.1093/nar/gkj139.PMC 1347501.PMID 16381901.

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Structure

Function

Interactions

References

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