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Climbazole

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Climbazole
Clinical data
Routes of
administration
topical
ATC code
  • none
Identifiers
  • (RS)-1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one[1]
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.048.870Edit this at Wikidata
Chemical and physical data
FormulaC15H17ClN2O2
Molar mass292.76 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • CC(C)(C)C(=O)C(n1ccnc1)Oc2ccc(cc2)Cl
  • InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 ☒N
  • Key:OWEGWHBOCFMBLP-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Climbazole is a topicalantifungal agent commonly used in the treatment of human fungal skin infections such asdandruff,seborrhoeic dermatitis andeczema.[2] Climbazole has shown a highin vitro andin vivo efficacy againstMalassezia spp. that appear to play an important role in the pathogenesis of dandruff.[2] Its chemical structure and properties are similar to otherazole fungicides such asketoconazole,clotrimazole andmiconazole.

Indications and formulations

[edit]

It is most commonly found as an active ingredient inOTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such aszinc pyrithione ortriclosan.[citation needed]

Side effects

[edit]

It may cause localized irritation of the skin with symptoms including redness, rashes and itching.[citation needed]

References

[edit]
  1. ^Chemical Properties of ClimbazoleArchived 2007-11-13 at theWayback Machine
  2. ^abWigger-Alberti W, Kluge K, Elsner P (August 2001). "[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]".Praxis.90 (33):1346–9.PMID 11534318.
Wall/
membrane
Ergosterol
inhibitors
Azoles (lanosterol 14α-
demethylase
inhibitors)
Imidazoles
Triazoles
Thiazoles
Polyene antimycotics
(ergosterol binding)
Squalene monooxygenase
inhibitors
Allylamines
Benzylamines
Others
β-glucan synthase
inhibitors
Intracellular
Pyrimidine analogues/
thymidylate synthase inhibitors
Mitotic inhibitors
Aminoacyl tRNA synthetase inhibitors
Others
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