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| Clinical data | |
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| Trade names | former Mandol |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| MedlinePlus | a601206 |
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| Routes of administration | Intramuscular,intravenous |
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| Pharmacokinetic data | |
| Protein binding | 75% |
| Eliminationhalf-life | 48 minutes |
| Excretion | Mostlyrenal, as unchanged drug |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.047.285 |
| Chemical and physical data | |
| Formula | C18H18N6O5S2 |
| Molar mass | 462.50 g·mol−1 |
| 3D model (JSmol) | |
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Cefamandole (INN, also known ascephamandole) is a second-generationbroad-spectrumcephalosporinantibiotic. The clinically used form of cefamandole is theformateestercefamandole nafate, aprodrug which is administeredparenterally. Cefamandole isno longer available in the United States.
The chemical structure of cefamandole, like that of several other cephalosporins, contains anN-methylthiotetrazole (NMTT or 1-MTT)side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can causehypoprothrombinemia (likely due toinhibition of theenzymevitamin K epoxide reductase) and a reaction withethanol similar to that produced bydisulfiram (Antabuse), due to inhibition ofaldehyde dehydrogenase. Vitamin K supplement is recommended during therapy, and consumption of ethanol and ethanol-containing substances is discouraged.
Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, urinary tract, and lower respiratory tract. The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms.
CO2 is generated during the normal constitution of cefamandole and ceftazidime, potentially resulting in an explosive-like reaction in syringes.[2]
