Cadherin EGF LAG seven-pass G-type receptor 1 also known asflamingo homolog 2 orcadherin family member 9 is aprotein that in humans is encoded by theCELSR1gene.[5][6]
The protein encoded by this gene is a member of the flamingo subfamily, part of thecadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact withcatenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and twolaminin G-like domains in theirectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and theEGF-like domains involved incell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.[6]
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members".J. Mol. Biol.299 (3):551–72.doi:10.1006/jmbi.2000.3777.PMID10835267.
Gross J, Grimm O, Ortega G, et al. (2002). "Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family".Psychiatr. Genet.11 (4):197–200.doi:10.1097/00041444-200112000-00003.PMID11807409.S2CID32757646.
Georgieva L, Nikolov I, Poriazova N, et al. (2004). "Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia".Psychiatr. Genet.13 (2):103–6.doi:10.1097/01.ypg.0000057486.14812.03.PMID12782967.S2CID28084057.
