Bradykinin receptor B1 (B1) is aG-protein coupled receptor encoded by theBDKRB1gene in humans. Its principalligand isbradykinin, a 9amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B1 receptor is one of two of G protein-coupled receptors that have been found which bindbradykinin and mediate responses to these pathophysiologic conditions.
B1 protein is synthesizedde novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.[5]
Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.[6]
"Bradykinin Receptors: B1".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-11-25.
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