Mechanism of action

Interactions

• BCL2L1^{[11][12][13][14][15][16][17][18][19][20][21]}
• BCL2A1^[11][22]
• BCL2L2^{[11][15][22][23]}
• Bcl-2^[11][17]
• MCL1^[11][22]
• S100A10^[24]
• YWHAQ^[11][24] and
• YWHAZ^[25]

See also

References

1. ^^abcGRCh38: Ensembl release 89: ENSG00000002330 –Ensembl, May 2017
2. ^^abcGRCm38: Ensembl release 89: ENSMUSG00000024959 –Ensembl, May 2017
3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^"BAD BCL2 associated agonist of cell death [Homo sapiens (Human)] - Gene - NCBI".
6. ^Adachi M, Imai K (2002)."The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2".Cell Death Differ.9 (11):1240–7.doi:10.1038/sj.cdd.4401097.PMID 12404123.
7. ^Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997)."Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11".Mol. Endocrinol.11 (12):1858–67.doi:10.1210/mend.11.12.0023.PMID 9369453.
8. ^Helmreich, E.J.M. (2001) The Biochemistry of Cell Signalling, pp. 238-43
9. ^E.J.M. (2001) The Biochemistry of Cell Signalling, pp. 242
10. ^Foster, T.C. et al. (2001) J. Neurosci. 21, 4066-4073, "Calcineurin Links Ca++ Dysregulation with Brain Aging"(
11. ^^abcdefChen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005)."Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function".Mol. Cell.17 (3):393–403.doi:10.1016/j.molcel.2004.12.030.PMID 15694340.
12. ^Jin Z, Xin M, Deng X (April 2005)."Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase".J. Biol. Chem.280 (16):16045–52.doi:10.1074/jbc.M413488200.PMID 15705582.
13. ^Strobel T, Tai YT, Korsmeyer S, Cannistra SA (November 1998)."BAD partly reverses paclitaxel resistance in human ovarian cancer cells".Oncogene.17 (19):2419–27.doi:10.1038/sj.onc.1202180.PMID 9824152.
14. ^Zhang H, Nimmer P, Rosenberg SH, Ng SC, Joseph M (August 2002). "Development of a high-throughput fluorescence polarization assay for Bcl-x(L)".Anal. Biochem.307 (1):70–5.doi:10.1016/S0003-2697(02)00028-3.PMID 12137781.
15. ^^abAyllón V, Cayla X, García A, Fleischer A, Rebollo A (July 2002)."The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad".Eur. J. Immunol.32 (7):1847–55.doi:10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7.PMID 12115603.
16. ^Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB, Wang HG (January 2000). "Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis".Nat. Cell Biol.2 (1):1–6.doi:10.1038/71316.PMID 10620799.S2CID 52847351.
17. ^^abYang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ (January 1995)."Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death".Cell.80 (2):285–91.doi:10.1016/0092-8674(95)90411-5.PMID 7834748.S2CID 10343291.
18. ^Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, Fesik SW (Dec 2000)."Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies".Protein Sci.9 (12):2528–34.doi:10.1110/ps.9.12.2528.PMC 2144516.PMID 11206074.
19. ^Chattopadhyay A, Chiang CW, Yang E (July 2001)."BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest".Oncogene.20 (33):4507–18.doi:10.1038/sj.onc.1204584.PMID 11494146.
20. ^Iwahashi H, Eguchi Y, Yasuhara N, Hanafusa T, Matsuzawa Y, Tsujimoto Y (November 1997). "Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy".Nature.390 (6658):413–7.Bibcode:1997Natur.390..413I.doi:10.1038/37144.PMID 9389483.S2CID 1936633.
21. ^Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG (November 2000)."PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition".Oncogene.19 (46):5291–7.doi:10.1038/sj.onc.1203901.PMID 11077446.
22. ^^abcBae J, Hsu SY, Leo CP, Zell K, Hsueh AJ (October 2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis".Apoptosis.6 (5):319–30.doi:10.1023/A:1011319901057.PMID 11483855.S2CID 23119757.
23. ^Holmgreen SP, Huang DC, Adams JM, Cory S (June 1999)."Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members".Cell Death Differ.6 (6):525–32.doi:10.1038/sj.cdd.4400519.PMID 10381646.
24. ^^abHsu SY, Kaipia A, Zhu L, Hsueh AJ (November 1997)."Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11".Mol. Endocrinol.11 (12):1858–67.doi:10.1210/mend.11.12.0023.PMID 9369453.
25. ^Yang H, Masters SC, Wang H, Fu H (June 2001). "The proapoptotic protein Bad binds the amphipathic groove of 14-3-3zeta".Biochim. Biophys. Acta.1547 (2):313–9.doi:10.1016/S0167-4838(01)00202-3.PMID 11410287.

Further reading

• Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (2004). "HIV/SIV escape from immune surveillance: focus on Nef".Curr. HIV Res.2 (2):141–51.doi:10.2174/1570162043484924.PMID 15078178.
• Jiang P, Du W, Wu M (2007)."p53 and Bad: remote strangers become close friends".Cell Res.17 (4):283–5.doi:10.1038/cr.2007.19.PMID 17404594.
• Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ (1995)."Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death".Cell.80 (2):285–91.doi:10.1016/0092-8674(95)90411-5.PMID 7834748.S2CID 10343291.
• Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ (1996)."Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)".Cell.87 (4):619–28.doi:10.1016/S0092-8674(00)81382-3.PMID 8929531.S2CID 860908.
• Wang HG, Rapp UR, Reed JC (1996)."Bcl-2 targets the protein kinase Raf-1 to mitochondria".Cell.87 (4):629–38.doi:10.1016/S0092-8674(00)81383-5.PMID 8929532.S2CID 16559750.
• Inohara N, Ding L, Chen S, Núñez G (1997)."harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)".EMBO J.16 (7):1686–94.doi:10.1093/emboj/16.7.1686.PMC 1169772.PMID 9130713.
• Zha J, Harada H, Osipov K, Jockel J, Waksman G, Korsmeyer SJ (1997)."BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity".J. Biol. Chem.272 (39):24101–4.doi:10.1074/jbc.272.39.24101.PMID 9305851.
• Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997)."Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11".Mol. Endocrinol.11 (12):1858–67.doi:10.1210/mend.11.12.0023.PMID 9369453.
• del Peso L, González-García M, Page C, Herrera R, Nuñez G (1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt".Science.278 (5338):687–9.Bibcode:1997Sci...278..687D.doi:10.1126/science.278.5338.687.PMID 9381178.
• Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, Chang S, Weeks S, Fritz LC, Oltersdorf T (1997)."Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins".J. Biol. Chem.272 (49):30866–72.doi:10.1074/jbc.272.49.30866.PMID 9388232.
• Huang DC, Adams JM, Cory S (1998)."The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4".EMBO J.17 (4):1029–39.doi:10.1093/emboj/17.4.1029.PMC 1170452.PMID 9463381.
• Blume-Jensen P, Janknecht R, Hunter T (1998)."The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136".Curr. Biol.8 (13):779–82.Bibcode:1998CBio....8..779B.doi:10.1016/S0960-9822(98)70302-1.PMID 9651683.S2CID 15596347.
• Strobel T, Tai YT, Korsmeyer S, Cannistra SA (1998)."BAD partly reverses paclitaxel resistance in human ovarian cancer cells".Oncogene.17 (19):2419–27.doi:10.1038/sj.onc.1202180.PMID 9824152.
• Song Q, Kuang Y, Dixit VM, Vincenz C (1999)."Boo, a novel negative regulator of cell death, interacts with Apaf-1".EMBO J.18 (1):167–78.doi:10.1093/emboj/18.1.167.PMC 1171112.PMID 9878060.
• Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3".Cancer Res.59 (3):533–7.PMID 9973195.
• Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (1999). "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD".Science.284 (5412):339–43.Bibcode:1999Sci...284..339W.doi:10.1126/science.284.5412.339.PMID 10195903.
• Holmgreen SP, Huang DC, Adams JM, Cory S (1999)."Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members".Cell Death Differ.6 (6):525–32.doi:10.1038/sj.cdd.4400519.PMID 10381646.
• Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J,Wolozin B (1999)."alpha-Synuclein shares physical and functional homology with 14-3-3 proteins".J. Neurosci.19 (14):5782–91.doi:10.1523/JNEUROSCI.19-14-05782.1999.PMC 6783081.PMID 10407019.
• Scheid MP, Schubert KM, Duronio V (1999)."Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase".J. Biol. Chem.274 (43):31108–13.doi:10.1074/jbc.274.43.31108.PMID 10521512.
• Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME (1999). "Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms".Science.286 (5443):1358–62.doi:10.1126/science.286.5443.1358.PMID 10558990.

External links