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BD1031

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Chemical compound

Pharmaceutical compound
BD1031
Identifiers
  • (R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine
CAS Number
ChemSpider
UNII
Chemical and physical data
FormulaC15H20Cl2N2
Molar mass299.24 g·mol−1
3D model (JSmol)
  • c1cc(c(cc1CCN2CCN3CCC[C@@H]3C2)Cl)Cl
  • InChI=1S/C15H20Cl2N2/c16-14-4-3-12(10-15(14)17)5-7-18-8-9-19-6-1-2-13(19)11-18/h3-4,10,13H,1-2,5-9,11H2/t13-/m1/s1
  • Key:IGVDQXLOMXGWKN-CYBMUJFWSA-N

BD1031 or(R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selectivesigma receptoragonist, with a reportedbinding affinity ofKi = 1 ± 0.2 nM for thesigma-1 receptor and 80 times selectivity over thesigma-2 receptor.[1] The enantiomer of BD1031 is known asBD1018.

Consistent with other reportedsigma receptoragonists, BD1031 increases the behavioural toxicity of cocaine in Swiss Webster mice.[1]

See also

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References

[edit]
  1. ^abMatsumoto RR, McCracken KA, Friedman MJ, Pouw B, De Costa BR, Bowen WD (2001). "Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice".Eur. J. Pharmacol.419 (2–3):163–74.doi:10.1016/s0014-2999(01)00968-2.PMID 11426838.
σ1
σ2
Unsorted
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