TGF-β3 is believed to regulate molecules involved incellular adhesion andextracellular matrix (ECM) formation during the process ofpalate development. Without TGF-β3, mammals develop a deformity known as acleft palate.[8][9] This is caused by failure ofepithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development oflungs in mammals, by also regulating cell adhesion and ECM formation in this tissue,[10] and controls wound healing by regulating the movements ofepidermal anddermal cells in injured skin.[5]
^Herpin A, Lelong C, Favrel P (May 2004). "Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans".Developmental and Comparative Immunology.28 (5):461–85.doi:10.1016/j.dci.2003.09.007.PMID15062644.
^Taya Y, O'Kane S, Ferguson MW (Sep 1999). "Pathogenesis of cleft palate in TGF-beta3 knockout mice".Development.126 (17):3869–79.doi:10.1242/dev.126.17.3869.PMID10433915.
^Dudas M, Nagy A, Laping NJ, Moustakas A, Kaartinen V (Feb 2004). "Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway".Developmental Biology.266 (1):96–108.doi:10.1016/j.ydbio.2003.10.007.PMID14729481.
^Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J (Dec 1995). "Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction".Nature Genetics.11 (4):415–21.doi:10.1038/ng1295-415.PMID7493022.S2CID22365206.
^De Crescenzo G, Pham PL, Durocher Y, O'Connor-McCourt MD (May 2003). "Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor capture on a biosensor surface using a new coiled-coil capture system demonstrates that avidity contributes significantly to high affinity binding".Journal of Molecular Biology.328 (5):1173–83.doi:10.1016/S0022-2836(03)00360-7.PMID12729750.
^Hart PJ, Deep S, Taylor AB, Shu Z, Hinck CS, Hinck AP (Mar 2002). "Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex".Nature Structural Biology.9 (3):203–8.doi:10.1038/nsb766.PMID11850637.S2CID13322593.
Barton DE, Foellmer BE, Du J, Tamm J, Derynck R, Francke U (1989). "Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family".Oncogene Research.3 (4):323–31.PMID3226728.
Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J (Dec 1995). "Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction".Nature Genetics.11 (4):415–21.doi:10.1038/ng1295-415.PMID7493022.S2CID22365206.
Nishida K, Sotozono C, Adachi W, Yamamoto S, Yokoi N, Kinoshita S (Mar 1995). "Transforming growth factor-beta 1, -beta 2 and -beta 3 mRNA expression in human cornea".Current Eye Research.14 (3):235–41.doi:10.3109/02713689509033520.PMID7796607.
Rampazzo A, Nava A, Danieli GA, Buja G, Daliento L, Fasoli G, Scognamiglio R, Corrado D, Thiene G (Jun 1994). "The gene for arrhythmogenic right ventricular cardiomyopathy maps to chromosome 14q23-q24".Human Molecular Genetics.3 (6):959–62.doi:10.1093/hmg/3.6.959.PMID7951245.
Zhao Y, Chegini N, Flanders KC (Oct 1994). "Human fallopian tube expresses transforming growth factor (TGF beta) isoforms, TGF beta type I-III receptor messenger ribonucleic acid and protein, and contains [125I]TGF beta-binding sites".The Journal of Clinical Endocrinology and Metabolism.79 (4):1177–84.doi:10.1210/jcem.79.4.7962292.PMID7962292.
Ambros RA, Kallakury BV, Malfetano JH, Mihm MC (Oct 1996). "Cytokine, cell adhesion receptor, and tumor suppressor gene expression in vulvar squamous carcinoma: correlation with prominent fibromyxoid stromal response".International Journal of Gynecological Pathology.15 (4):320–5.doi:10.1097/00004347-199610000-00004.PMID8886879.
Djonov V, Ball RK, Graf S, Mottaz AE, Arnold AM, Flanders K, Studer UE, Merz VW (May 1997). "Transforming growth factor-beta 3 is expressed in nondividing basal epithelial cells in normal human prostate and benign prostatic hyperplasia, and is no longer detectable in prostate carcinoma".The Prostate.31 (2):103–9.doi:10.1002/(SICI)1097-0045(19970501)31:2<103::AID-PROS5>3.0.CO;2-O.PMID9140123.S2CID22734222.
Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, Takigawa M, Nakanishi T, Takehara K (Oct 1999). "Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model".Journal of Cellular Physiology.181 (1):153–9.doi:10.1002/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K.PMID10457363.S2CID21284888.
