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Angiopoietin-related protein 1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

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ANGPTL1
Identifiers
AliasesANGPTL1, ANG3, ANGPT3, ARP1, AngY, UNQ162, dJ595C2.2, angiopoietin like 1
External IDsOMIM:603874;MGI:1919963;HomoloGene:128467;GeneCards:ANGPTL1;OMA:ANGPTL1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ANGPTL1
Genomic location for ANGPTL1
Band1q25.2Start178,849,535bp[1]
End178,871,077bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ANGPTL1
Genomic location for ANGPTL1
Band1|1 G3Start156,666,132bp[2]
End156,688,648bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left uterine tube

  • smooth muscle tissue

  • Achilles tendon

  • tendon of biceps brachii

  • popliteal artery

  • tibial arteries

  • muscle layer of sigmoid colon

  • right ovary

  • left coronary artery

  • Descending thoracic aorta
Top expressed in
  • basilar part of occipital bone

  • intercostal muscle

  • squamous epithelium

  • condyle

  • mesothelium

  • mesothelium of peritoneum

  • rib

  • human fetus

  • sphenoid bone

  • dermis
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9068

72713

Ensembl

ENSG00000116194

ENSMUSG00000033544

UniProt

O95841

Q640P2

RefSeq (mRNA)

NM_004673
NM_001376763

NM_028333

RefSeq (protein)

NP_004664
NP_001363692

NP_082609

Location (UCSC)Chr 1: 178.85 – 178.87 MbChr 1: 156.67 – 156.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Angiopoietin-related protein 1 also known asangiopoietin-3 (ANG-3) is aprotein that in humans is encoded by the ANGPTL1gene.[5][6][7]

Function

[edit]

Angiopoietins are members of thevascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium.Angiopoietin-1,angiopoietin-2, andangiopoietin-4 participate in the formation of blood vessels.

The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues withmRNA levels highest in highly vascularized tissues. This protein was found to be asecretory protein that does not act as anendothelial cellmitogen in vitro.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000116194Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000033544Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999)."Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3".FEBS Lett.443 (3):353–6.doi:10.1016/S0014-5793(99)00008-3.PMID 10025962.S2CID 27230019.
  6. ^Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1".Genomics.44 (1):94–100.doi:10.1006/geno.1997.4872.PMID 9286704.
  7. ^ab"Entrez Gene: ANGPTL1 angiopoietin-like 1".

External links

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Further reading

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