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| Other names | AET; Androst-5-ene-3β,7β,17β-triol; β-Androstenetriol; β-AET |
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| Formula | C19H30O3 |
| Molar mass | 306.446 g·mol−1 |
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Androstenetriol (AET,androst-5-ene-3β,7β,17β-triol,β-androstenetriol, orβ-AET) is asteroid produced in theadrenal glands as ametabolite ofdehydroepiandrosterone (DHEA).[1] It is believed to have similar effects as DHEA andandrostenediol.[2] A study in rodents found that the compound was a weakandrogen andestrogen, but did not bind to theandrogen,estrogen,progesterone, orglucocorticoid receptors.[1]Syntheticanalogues of androstenetriol such asbezisterim (HE3286, NE3107; the 17α-ethynylatedderivative) have been developed and are under study.[3][4][5]
Bezisterim, a derivative of the natural anti-inflammatory steroid β-AET, is an orally active NF-κB inhibitor. It has been shown to protect neurons by reducing inflammation and improving glucose utilization, thereby promoting brain health. Clinical results have demonstrated that bezisterim can improve cognition and biomarker levels in AD patients and is currently in phase III clinical trials [68].
