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Allobarbital

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Allobarbital
Clinical data
Other names5,5-Diallylbarbituric acid, Allobarbital
Drug classBarbiturate
ATC code
Legal status
Legal status
Identifiers
  • 5,5-di(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.000.129Edit this at Wikidata
Chemical and physical data
FormulaC10H12N2O3
Molar mass208.217 g·mol−1
3D model (JSmol)
  • O=C1NC(=O)NC(=O)C1(C\C=C)C\C=C
  • InChI=1S/C10H12N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-4H,1-2,5-6H2,(H2,11,12,13,14,15) checkY
  • Key:FDQGNLOWMMVRQL-UHFFFAOYSA-N checkY
  (verify)

Allobarbital, also known asallobarbitone and branded asDial,Cibalgine (in combination withaminophenazone), orDial-Ciba (in combination withethyl carbamate), is abarbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working forCIBA. It was used primarily as ananticonvulsant[2] although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity ofanalgesic drugs, and use in the treatment ofinsomnia andanxiety.

Allobarbital was never particularly widely used compared to better known barbiturates such asphenobarbital andsecobarbital, although it saw more use in some European countries such asBulgaria andSlovakia.[3] In Poland, it was used until the 2010's, but only as compound.[4]

References

[edit]
  1. ^Anvisa (2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-04-04).Archived from the original on 2023-08-03. Retrieved2023-08-16.
  2. ^Chocholová L, Radil-Weiss T (1971). "Effect of allobarbital on focal epilepsy in rats".Physiologia Bohemoslovaca.20 (4):325–34.PMID 4335127.
  3. ^Getova D, Georgiev V (1987). "GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists".Acta Physiologica et Pharmacologica Bulgarica.13 (3):43–50.PMID 3439474.
  4. ^"APTECZKA BABUNI - KROPLE ŻOŁĄDKOWE KROPLE 20 G" [GRANDMA'S FIRST AID KIT - DROPS - STOMACH DROPS 20 G].Domzdrowia.pl (in Polish).Archived from the original on October 31, 2007. RetrievedMarch 10, 2013.
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