| Alezzandrini syndrome | |
|---|---|
| Specialty | Dermatology |
| Symptoms | Loss of vision, facialvitiligo, sound sensitivity |
| Causes | Unknown |
| Treatment | None |
| Deaths | Unknown |
Alezzandrini syndrome is a very rare syndrome characterized by a unilateral degenerativeretinitis, followed after several months by ipsilateralvitiligo on the face and ipsilateralpoliosis.[1]: 864 [2]Deafness may also be present.[1]: 864 [3]
Initially, there is a progressive loss of visual acuity, mostly in one eye. Infected areas experience pigmentation loss in the skin and hair. Unilateral tapetoretinal degeneration accompanied by the ipsilateral appearance of facialvitiligo andpoliosis is the hallmark of Alezzandrini syndrome.[4]
It is unknown what causes Alezzandrini syndrome.[4]
The clinical presentation is the basis for the diagnosis.[4]
Psoralen plus ultraviolet A (PUVA) treatment is an option for cases with extensive depigmentation.Topical steroids may be used to treatvitiligo in specific areas. People who havevitiligo should wear sunscreen to avoid getting sunburned and developingskin cancer later on.[4]