General aldol structure showing the α and 𝛽 positions of carbons relative to the carbonyl. When R" is -H, it is an aldol, when R" is a carbon, it is a ketol.
Inorganic chemistry, analdol is a structure consisting of ahydroxy group (-OH) two carbons away from either analdehyde or aketone. The name combines the suffix 'ol' from the alcohol and the prefix depending on thecarbonyl group, either 'ald' for an aldehyde, or 'ket' for a ketone, in which case it referred to as a 'ketol'. An aldol may also use the term β-hydroxy aldehyde (or β-hydroxy ketone for a ketol). The term "aldol" may refer to3-hydroxybutanal.[1][2]
Aldols are the product of acarbon-carbon bond-formation reaction, giving them wide applicability as a precursor for a variety of other compounds.
Possiblestereochemical configurations for chiral aldols. R/S configurations ofchiral centers: A: OH is 4R, R-group is 3R B: OH is 4S, R-group is 3S C: OH is 4R, R-group is 3S D: OH is 4S, R-group is 3R
Aldols are usually synthesized from analdol addition reaction using two aldehydes or an aldehyde and a ketone for a ketol.[1] These reactions may also be done intramolecularly to form 5 or 6 member rings or for stereoselective syntheses in the active area ofasymmetric synthesis.
^PubChem."CID 21282929".National Center for Biotechnology Information. Retrieved2023-04-15.
^Zhang, Yanping; Mu, Hongliang; Pan, Li; Wang, Xuling; Li, Yuesheng (21 May 2018). "Robust Bulky [P,O] Neutral Nickel Catalysts for Copolymerization of Ethylene with Polar Vinyl Monomers".ACS Catal.8 (7):5963–5976.doi:10.1021/acscatal.8b01088 – via ACS Publications.
^Schetter, Bernd; Mahrwald, Rainer (2006). "Modern aldol methods for the total synthesis of polyketides".Angewandte Chemie International Edition.45 (45):7506–25.doi:10.1002/anie.200602780.PMID17103481.
