It is available as ageneric medication.[4] In 2022, it was the 292nd most commonly prescribed medication in the United States, with more than 400,000 prescriptions.[5][6]
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.[7]
The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;[8] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
^Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients".The Journal of Dermatological Treatment.22 (4):197–205.doi:10.3109/09546631003681094.PMID20666678.S2CID34631151.
^Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, et al. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study".The British Journal of Dermatology.165 (2):383–90.doi:10.1111/j.1365-2133.2011.10374.x.PMID21495995.S2CID21793660.
1 Brand owned byGeneral Mills; Produced by General Mills in the U.S. and Canada. Produced byCereal Partners under the Nestlé brand elsewhere.2 Brand owned byGeneral Mills; U.S. and Canadian production rights controlled by Nestlé under license.3 U.S. production rights owned byThe Hershey Company.4 U.S. rights and production owned by theSmarties Candy Company with a different product.5 U.S. rights and specific trade dress owned by Nestlé; rights elsewhere owned byAssociated British Foods.6 Produced by Cereal Partners, branded as Nestlé.7 Brand owned byPost Foods; Produced by Cereal Partners and branded as Nestlé in the U.K. and Ireland.8 Philippine production rights owned byAlaska Milk Corporation.9 Singaporean, Malaysian and Thai production rights owned byFraser and Neave.10 Used only in Indonesia, Thailand, and Cambodia.11 Used only in the Philippines.12 U.S. production rights owned by theFerrara Candy Company.13NA rights and specific trade dress to all packaged coffee and other products under the Starbucks brand owned by Nestlé since 2019.14 Brand owned byMars, sold by Nestlé in Canada.15 Produced byFroneri in the U.S. since 2020.
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