Acetonedicarboxylic acid,3-oxoglutaric acid orβ-ketoglutaric acid is a simpledicarboxylic acid with the formulaO=C(CH2CO2H)2. β-Ketoglutarate does not have the biological activity exhibited byα-ketoglutarate.[2]
Acetonedicarboxylic acid and its esters such as dimethylacetonedicarboxylate are primarily used as building blocks in the synthesis of heterocyclic rings[4] and in theWeiss–Cook reaction.[5]
Acetonedicarboxylic acid is well known to be used in the Robinsontropinone synthesis.
The presence of β-ketoglutaric acid in human urine is diagnostic for the harmful gut flora such asCandida albicans.[6]
^Stanovnik, Branko; Grošelj, Uroš (2010). "Dialkyl Acetone-1,3-Dicarboxylates and their Mono- and bis(Dimethylamino)methylidene Derivatives in the Synthesis of Heterocyclic Systems".Advances in Heterocyclic Chemistry Volume 100. Vol. 100. pp. 145–174.doi:10.1016/S0065-2725(10)10005-1.ISBN9780123809360.
^Korman, Matthew; Paz, Eric; Franklin, Tylor; Lewandowski, Nicholas R.; Sullivan, Bethany; Imhoff, Andrea M.; Fisher, Luke; Bichler, Katherine A.; Van Ornum, Scott G. (2020). "Process Development of the Weiss–Cook Reaction for the Preparation of cis-1,5-Dimethylbicyclo[3.3.0]octane-3,7-dione in the Undergraduate Organic Laboratory".Journal of Chemical Education.97 (10):3835–3838.Bibcode:2020JChEd..97.3835K.doi:10.1021/acs.jchemed.9b00653.S2CID225248640.
^Schmidt, Michael A,Tired of Being Tired: Overcoming Chronic Fatigue and Low Energy
