AT-rich interactive domain-containing protein 4B is aprotein that in humans is encoded by theARID4Bgene.[5][6]
This gene encodes a protein with sequence similarity toretinoblastoma-binding protein-1. The encoded protein is a subunit of thehistone deacetylase-dependentSIN3A transcriptionalcorepressor complex, which functions in diverse cellular processes includingproliferation,differentiation,apoptosis,oncogenesis, andcell fate determination. The gene product is recognized byIgGantibody isolated from abreast cancer patient and appears to be amolecular marker associated with a broad range of human malignancies. Alternate transcriptionalsplice variants encoding differentisoforms have been characterized.[6]
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