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ARCT-021

From Wikipedia, the free encyclopedia
Vaccine candidate against COVID-19

This article is about the American vaccine. For other uses, seeArcturus COVID-19 vaccine.
Pharmaceutical compound
ARCT-021
Vaccine description
TargetSARS-CoV-2
Vaccine typesa-mRNA
Clinical data
Other namesLUNAR-COV19
Routes of
administration
Intramuscular
Identifiers
CAS Number
Part ofa series on the
COVID-19 pandemic
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
virus iconCOVID-19 portal

ARCT-021, also known asLUNAR-COV19, is aCOVID-19 vaccine candidate developed byArcturus Therapeutics.

Medical uses

[edit]

It requires theintramuscular injection with a single dose.[2]

Pharmacology

[edit]

ARCT-021 is anself-amplifyingmRNA vaccine.[3][4]

History

[edit]

Arcturus Therapeutics partnered with Singapore'sDuke–NUS Medical School to develop aCOVID-19 vaccine.[5] The company also partnered withCatalent, a contract development and manufacturing organization, to manufacture multiple batches of Arcturus' COVID-19mRNA vaccine candidate.[6]

Clinical trials

[edit]

LUNAR-COV19 clinical trials in humans began in July 2020.[7] On 4 January 2021, Arcturus Therapeutics started Phase-2 clinical trials.[8]

Economics

[edit]

Arcturus has entered into development and supply agreements with theEconomic Development Board of Singapore and supply agreements with theIsrael Ministry of Health for LUNAR-COV19.[9][10]

References

[edit]
  1. ^"Patent Landscape Report COVID-19-related vaccines and therapeutics"(PDF).
  2. ^"Arcturus Therapeutics Announces First Quarter 2021 Company Overview and Financial Results and Provides New Clinical Data". Businesswire. 10 May 2021. Retrieved9 September 2021.
  3. ^Low JG, de Alwis R, Chen S, Kalimuddin S, Leong YS, Mah TK, Yuen N, Tan HC, Zhang SL, Sim JX, Chan YF, Syenina A, Yee JX, Ong EZ, Sekulovich R, Sullivan BB, Lindert K, Sullivan SM, Chivukula P, Hughes SG, Ooi EE (December 2022)."A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine".npj Vaccines.7 (1): 161.doi:10.1038/s41541-022-00590-x.PMC 9745278.PMID 36513697.
  4. ^"Arcturus Therapeutics Announces that it has Initiated Dosing of its COVID-19 STARR mRNA Vaccine Candidate, LUNAR-COV19 (ARCT-021) in a Phase 1/2 study". Globe Newswire. 11 August 2020.
  5. ^Teo J (15 April 2020)."Coronavirus: Clinical trials for Singapore's vaccine project could start in August".The Straits Times. Retrieved27 April 2020.
  6. ^Stanton D (6 May 2020)."With Arcturus, Catalent bags another COVID project".Bioprocess Insider. Retrieved8 May 2020.
  7. ^Clinical trial numberNCT04480957 for "Phase 1/2 Ascending Dose Study of Investigational SARS-CoV-2 Vaccine ARCT-021 in Healthy Adult Subjects" atClinicalTrials.gov
  8. ^"Arcturus Therapeutics Receives FDA Allowance to Proceed with Phase 2 Study of ARCT-021 (LUNAR-COV19) Vaccine Candidate in the". Bloomberg. 4 January 2021. Retrieved17 January 2021.
  9. ^Anwar N (26 November 2020)."Singapore's co-developed vaccine candidate is in 'good shape' for delivery in 2021". CNBC. Retrieved18 March 2021.
  10. ^Cheok M, Mookerjee I (5 August 2020)."Singapore Will Get First Claim to Any Successful Arcturus Vaccine". Bloomberg. Retrieved18 March 2021.

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