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ACP2

From Wikipedia, the free encyclopedia
Protein-coding gene in humans
ACP2
Identifiers
AliasesACP2, acid phosphatase 2, lysosomal, LAP
External IDsOMIM:171650;MGI:87882;HomoloGene:1217;GeneCards:ACP2;OMA:ACP2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ACP2
Genomic location for ACP2
Band11p11.2|11p12-p11Start47,239,302bp[1]
End47,248,906bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ACP2
Genomic location for ACP2
Band2 E1|2 50.54 cMStart91,033,230bp[2]
End91,044,443bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • body of pancreas

  • right adrenal gland

  • left adrenal gland

  • right adrenal cortex

  • stromal cell of endometrium

  • jejunal mucosa

  • left adrenal cortex

  • mucosa of transverse colon

  • salivary gland
Top expressed in
  • spermatocyte

  • medial dorsal nucleus

  • stroma of bone marrow

  • spermatid

  • dentate gyrus of hippocampal formation granule cell

  • choroid plexus of fourth ventricle

  • medial geniculate nucleus

  • ascending aorta

  • aortic valve

  • genital tubercle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

53

11432

Ensembl

ENSG00000134575

ENSMUSG00000002103

UniProt

P11117

P24638

RefSeq (mRNA)
NM_001131064
NM_001302489
NM_001302490
NM_001302491
NM_001302492

NM_001610
NM_001357016

NM_007387
NM_001357067

RefSeq (protein)
NP_001289418
NP_001289419
NP_001289420
NP_001289421
NP_001601

NP_001343945

NP_031413
NP_001343996

Location (UCSC)Chr 11: 47.24 – 47.25 MbChr 2: 91.03 – 91.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysosomal acid phosphatase is anenzyme that in humans is encoded by theACP2gene.[5][6]

Lysosomalacid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct fromred cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyzeorthophosphoric monoesters toalcohol andphosphate.Acid phosphatase deficiency is caused bymutations in the ACP2 (beta subunit) andACP3 (alpha subunit) genes.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000134575Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000002103Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11".Cytogenet Cell Genet.16 (1–5):231–4.doi:10.1159/000130598.PMID 975882.
  6. ^ab"Entrez Gene: ACP2 acid phosphatase 2, lysosomal".

Further reading

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External links

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