TheAAMDC gene encodes an AMDC orAdipogenesis Associated Mth938 Domain Containingprotein that is integral to various cellular processes. The protein is involved inlipid metabolism, specificallyadipogenesis, and plays a role insignal transduction as anoncoprotein.[1]
The AAMDC protein is found in both the cytoplasmic and nuclear compartments of the cell.[2]
- ^Xiao, Rong; Li, Chengping; Wang, Chao; Cao, Yang; Zhang, Lichun; Guo, Yan; Xin, Youzhi; Zhang, Haiyan; Zhou, Guoli (July 2019)."Adipogenesis associated Mth938 domain containing (AAMDC) protein expression is regulated by alternative polyadenylation and microRNAs".FEBS Letters.593 (14):1724–1734.doi:10.1002/1873-3468.13449.ISSN 1873-3468.PMID 31116411.
- ^Golden, Emily; Rashwan, Rabab; Woodward, Eleanor A.; Sgro, Agustin; Wang, Edina; Sorolla, Anabel; Waryah, Charlene; Tie, Wan Jun; Cuyàs, Elisabet; Ratajska, Magdalena; Kardaś, Iwona; Kozlowski, Piotr; Johnstone, Elizabeth K. M.; See, Heng B.; Duffy, Ciara (2021-03-26)."The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer".Nature Communications.12 (1): 1920.Bibcode:2021NatCo..12.1920G.doi:10.1038/s41467-021-22101-7.hdl:11343/277935.ISSN 2041-1723.PMC 7998036.PMID 33772001.
