| 2-ethylmalate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.3.6 | ||||||||
| CAS no. | 9024-01-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, a2-ethylmalate synthase (EC2.3.3.6) is anenzyme thatcatalyzes thechemical reaction
The 3substrates of this enzyme areacetyl-CoA,H2O, and2-oxobutanoate, whereas its twoproducts are(R)-2-ethylmalate andCoA.
This enzyme belongs to the family oftransferases, specifically thoseacyltransferases that convert acyl groups into alkyl groups on transfer. Thesystematic name of this enzyme class isacetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming). Other names in common use include(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating),2-ethylmalate-3-hydroxybutanedioate synthase,propylmalate synthase, andpropylmalic synthase. This enzyme participates inpyruvate metabolism.
