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1-Decanol

From Wikipedia, the free encyclopedia
1-Decanol[1]
Skeletal formula
Skeletal formula
Space-filling model
Space-filling model
Names
Preferred IUPAC name
Decan-1-ol
Other names
decyl alcohol
n-decyl alcohol
capric alcohol
epal 10
antak
agent 504
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard100.003.597Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C10H21OH/c1-2-3-4-5-6-7-8-9-10-11/h11H,2-10H2,1H3 checkY
    Key: MWKFXSUHUHTGQN-UHFFFAOYSA-N checkY
  • InChI=1/C10H21OH/c1-2-3-4-5-6-7-8-9-10-11/h11H,2-10H2,1H3
    Key: MWKFXSUHUHTGQN-UHFFFAOYAN
  • OCCCCCCCCCC
Properties
C10H21OH
Molar mass158.28 g/mol
AppearanceViscous liquid
Density0.8297 g/cm3
Melting point6.4 °C (43.5 °F; 279.5 K)
Boiling point232.9 °C (451.2 °F; 506.0 K)
37 mg/L at 20°C[2]
logP4.57
Viscosity12.048 mPa.s (@ 25 °C)
Hazards
Flash point108 °C (226 °F; 381 K)
Safety data sheet (SDS)Oxford MSDS
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Chemical compound

1-Decanol is a straight chainfatty alcohol with tencarbonatoms and the molecular formula C10H21OH. It is a colorless to light yellow viscous liquid that is insoluble in water and has an aromatic odor.[3] The interfacial tension against water at 20 °C is 8.97 mN/m.

Production

[edit]

Decanol can be prepared by thehydrogenation ofdecanoic acid, which occurs in modest quantities incoconut oil (about 10%) andpalm kernel oil (about 4%). It may also be produced synthetically via theZiegler process.

Uses

[edit]

Decanol is used in the manufacture ofplasticizers,lubricants,surfactants and solvents. Its ability to permeate the skin has led to it being investigated as a penetration enhancer fortransdermal drug delivery.[4][5]

Safety

[edit]

Like other medium chain fatty alcohols, 1-decanol is able to permeate the skin which can lead to irritation.

References

[edit]
  1. ^Merck Index, 12th Edition,2911.
  2. ^"1-Decanol".
  3. ^"Material Safety Data Sheet - Decyl alcohol, 99%".fscimage.fishersci.com.Archived from the original on 2021-09-01. Retrieved2021-09-01.
  4. ^Kanikkannan, N; Singh, Mandip (November 2002). "Skin permeation enhancement effect and skin irritation of saturated fatty alcohols".International Journal of Pharmaceutics.248 (1–2):219–228.doi:10.1016/S0378-5173(02)00454-4.PMID 12429475.
  5. ^Williams, Adrian C; Barry, Brian W (March 2004). "Penetration enhancers".Advanced Drug Delivery Reviews.56 (5):603–618.doi:10.1016/j.addr.2003.10.025.PMID 15019749.
By consumption
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(1°)
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Straight-chain
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C1 — C9
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