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TheMEROPS database is an information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them. The Summary page describing a given peptidase can be reached by use of an index under itsName,MEROPSIdentifier or sourceOrganism. The Summary describes the classification and nomenclature of the peptidase and offers links to supplementary pages showing sequence identifiers, the structure if known, literature references and more.
TheMEROPS database uses an hierarchical, structure-based classification of the peptidases. In this, each peptidase is assigned to aFamily on the basis of statistically significant similarities in amino acid sequence, and families that are thought to be homologous are grouped together in aClan. There is a Summary page for each family and clan, and these again have indexes. Each of the Summary pages offers links to supplementary pages.
Please use the Menu in the side-bar to navigate through the database, and consult theAbout pages to discover more. To reach the Inhibitors side ofMEROPS click the button at the top of the sidebar.
TheMEROPS team are Neil D. Rawlings and Alan J. Barrett at the EMBL-European Bioinformatics Institute, Cambridge CB10 1SD, UK (merops@ebi.ac.uk).
Many authors find it useful to include data fromMEROPS in their publications, and that is very much what we are here for, but please cite the appropriate publication as well as the URL when you do so. This is:Rawlings, N.D., Barrett, A.J., Thomas, P.D., Huang, X., Bateman, A. & Finn, R.D. (2018) The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database.Nucleic Acids Res46, D624-D632. Thank you!
