OBJECTIVE: Current knowledge of the relationship between epilepsy and schizophrenia-like psychosis is examined, and the proposed pathogenetic mechanisms are evaluated. METHOD: The author provides an overview of the published literature on epilepsy and ...

Regular Article

March 1998

Effect of a Haloperidol Challenge on Regional Brain Metabolism in Neuroleptic-Responsive and Nonresponsive Schizophrenic Patients

Pages:337–343
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.337

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OBJECTIVE: The CNS metabolic response to a neuroleptic challenge in treatment-responsive and nonresponsive schizophrenic patients was measured in order to examine the relation between treatment outcome and the capacity to alter neurochemical function in ...

March 1998

Association Between Decline in Brain Dopamine Activity With Age and Cognitive and Motor Impairment in Healthy Individuals

Pages:344–349
Published Online:15 January 2015

https://doi.org/10.1176/ajp.155.3.344

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OBJECTIVE: Although it is documented that brain dopamine activity declines with age, the functional significance of this is not known. This study assessed the relation between measures of brain dopamine activity and indexes of motor and cognitive function ...

March 1998

Experience of Negative Symptoms: Comparison of Schizophrenic Patients to Patients With a Depressive Disorder and to Normal Subjects

Jean-Paul Selten,M.D., Ph.D.,
Hajo B.P.E. Gernaat,M.D.,
Willem A. Nolen,M.D., Ph.D.,
Durk Wiersma,Ph.D., and
Robert J. van den Bosch,M.D., Ph.D.

Pages:350–354
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.350

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OBJECTIVE: Three hypotheses were tested: 1) schizophrenic patients would report more impairments on a self-rating scale for negative symptoms than normal subjects and attribute higher levels of distress to these impairments, 2) schizophrenic patients ...

March 1998

Schizophrenia as a Long-Term Outcome of Pregnancy, Delivery, and Perinatal Complications: A 28-Year Follow-Up of the 1966 North Finland General Population Birth Cohort

Peter B. Jones,Ph.D., M.R.C.Psych.,
Paula Rantakallio,M.D., Ph.D.,
Anna-Liisa Hartikainen,M.D., Ph.D.,
Matti Isohanni,M.D., Ph.D., and
Pirkko Sipila,M.D.

Pages:355–364
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.355

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OBJECTIVE: The 1966 North Finland general population birth cohort was studied to determine whether abnormalities during pregnancy, delivery, and the neonatal period are associated with adult-onset schizophrenia. METHOD: The authors included all 11,017 ...

March 1998

Alteration in the Recommended Dosing Schedule for Risperidone

Pages:365–366
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.365

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OBJECTIVE: The authors' goal was to study the recommended dose schedule for risperidone. METHOD: They obtained computerized pharmacy data on 1,283 inpatients with the diagnoses of schizophrenia or schizoaffective disorder who were treated with ...

March 1998

Randomized, Placebo-Controlled Trial of Paroxetine Versus Imipramine in Depressed HIV-Positive Outpatients

Pages:367–372
Published Online:23 January 2015

https://doi.org/10.1176/ajp.155.3.367

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OBJECTIVE: This study examined whether a selective serotonin reuptake inhibitor (paroxetine) had comparable efficacy but greater tolerability than a tricyclic antidepressant (imipramine) in depressed patients with HIV infection. METHOD: Seventy-five HIV-...

March 1998

Selective Alteration of Personality and Social Behavior by Serotonergic Intervention

Pages:373–379
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.373

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OBJECTIVE: The authors sought to test the causal hypothesis that serotonergic function modulates aspects of the normal spectrum of individual differences in affective experience and social behavior in humans. METHOD: A selective serotonin reuptake ...

March 1998

Brain Elimination Half-Life of Fluvoxamine Measured by¹⁹F Magnetic Resonance Spectroscopy

Pages:380–384
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.380

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OBJECTIVE: This study used fluorine-19 magnetic resonance spectroscopy (¹⁹F MRS) to characterize the elimination of fluvoxamine from the human brain after abrupt drug discontinuation. The elimination half-lives of fluvoxamine in brain and plasma were ...

March 1998

Aborted Suicide Attempts: A New Classification of Suicidal Behavior

Pages:385–389
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.385

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OBJECTIVE: With the goal of ultimately finding early suicide predictors, the authors undertook a study of aborted suicide attempts. They defined such an attempt as an event in which an individual comes close to attempting suicide but does not complete the ...

March 1998

Homicide-Suicide in Older Persons

Donna Cohen,Ph.D.,
Maria Llorente,M.D., and
Carl Eisdorfer,Ph.D., M.D.

Pages:390–396
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.390

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OBJECTIVE: The objective of this study was to determine the annual incidence of homicide-suicide and to compare patterns and antecedents in old and young spousal/consortial cases. METHOD: Homicide-suicide cases were ascertained in four medical examiner ...

March 1998

Characterizing Psychiatry With Findings From the 1996 National Survey of Psychiatric Practice

Pages:397–404
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.397

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OBJECTIVE: The authors' goal was to characterize psychiatric practice by reporting findings from the 1996 National Survey of Psychiatric Practice. METHOD: A random sample of 1,481 APA members was selected to participate in the study; 1,375 APA members ...

March 1998

Psychiatrist and Nonphysician Mental Health Provider Staffing Levels in Health Maintenance Organizations

Pages:405–408
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.405

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OBJECTIVE: This study attempts to determine the ratio of full-time-equivalent psychiatrists to members and that of nonphysician mental health professionals to psychiatrists in staff and group model health maintenance organizations (HMOs), and to compare ...

March 1998

Misuses and Misunderstandings of Boundary Theory in Clinical and Regulatory Settings

Thomas G. Gutheil,M.D., and
Glen O. Gabbard,M.D.

Pages:409–414
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.409

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OBJECTIVE: This paper outlines a number of misapplications of boundary theory in both regulatory settings and clinical situations. METHOD: The authors review clinical vignettes that illustrate the difference between boundary crossings, which lead to ...

Clinical Case Conference

March 1998

Psychiatric Evaluation of a “Monk” Requesting Castration: A Patient's Fable, With Morals

Pages:415–420
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.415

Images in Psychiatry

March 1998

: Donald W. Winnicott, 1896–1971

Page:421
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.421

Brief Report

March 1998

Genomic Discordance Between Monozygotic Twins Discordant for Schizophrenia

Pages:422–424
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.422

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OBJECTIVE: Genomic DNA of monozygotic twins discordant for schizophrenia was analyzed to determine whether their genomes were truly identical. METHOD: The subjects were monozygotic male twins, one of whom had DSM-III-R schizophrenia, undifferentiated ...

March 1998

P300 Latency in Geriatric Depression

Pages:425–427
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.425

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OBJECTIVE: The purpose of this study was to determine if P300 latency is prolonged in geri~atric depression and if longer P300 latency and deficits in initiation and errors of perseveration in depressed elderly patients are related to risk factors for ...

March 1998

Negative Attributional Style in Seasonal and Nonseasonal Depression

Pages:428–430
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.428

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OBJECTIVE: There is a substantial relationship between dysfunctional cognitions and the clinical course of major depression. This study examined whether this association extends to patients with seasonal affective disorder. METHOD: A revised version of ...

March 1998

Psychiatric Symptoms and Syndromes Among Adolescent Children of Parents With Lithium-Responsive or Lithium-Nonresponsive Bipolar Disorder

Anne Duffy,M.D., M.Sc.,
Martin Alda,M.D.,
Stan Kutcher,M.D.,
Carrie Fusee,B.A., and
Paul Grof,M.D., Ph.D.

Pages:431–433
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.431

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OBJECTIVE: The purpose of this pilot study was to describe the initial course of psychiatric illness in the adolescent children of parents with bipolar disorder who were divided into two groups on the basis of their response to long-term lithium ...

March 1998

Sex Differences in Blood-Oxygenation-Level-Dependent Functional MRI With Primary Visual Stimulation

Jonathan M. Levin,M.D., M.P.H.,
Marjorie H. Ross,M.D.,
Jack H. Mendelson,M.D.,
Nancy K. Mello,Ph.D.,
Bruce M. Cohen,M.D., Ph.D., and
Perry F. Renshaw,M.D., Ph.D.

Pages:434–436
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.434

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OBJECTIVE: The authors evaluated the effect of sex on data derived from activation studies using blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (MRI). METHOD: Gradient echo-echo planar imaging was used to measure BOLD ...

March 1998

Self-Report Ratings and Informants' Ratings of Personalities of Depressed Outpatients

Pages:437–438
Published Online:1 March 1998

https://doi.org/10.1176/ajp.155.3.437

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OBJECTIVE: This study sought to determine whether personality traits of depressed pa~tients could be assessed similarly by informants and self-reports of the patients themselves. METHOD: Forty-six depressed outpatients completed the self-report (first-...