American Journal of Psychiatry
Volume 176, Issue 3
March 2019
Cover: The image displays the seven white matter tracts investigated in the study by Tromp et al. (p. 208) that found reduced structural integrity of the uncinate fasciculus (in green), which connects the prefrontal cortex to limbic structures, in boys but not girls with anxiety disorders.
Editor’s Note
March 2019
New Insights Highlighting Neurodevelopmental Issues That Predispose to Childhood and Adolescent Psychopathology
- Ned H. Kalin,M.D.
- Pages:171–172
- Published Online:1 March 2019
Treatment in Psychiatry
CME
March 2019Supporting Providers After Drug Overdose Death
- Amy M. Yule,M.D.,
- Frances R. Levin,M.D.
- Pages:173–178
- Published Online:1 March 2019
Reviews and Overviews
March 2019
Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders
- Heidi C. Meyer,Ph.D.,
- Francis S. Lee,M.D.,Ph.D.
- Pages:179–185
- Published Online:1 March 2019
https://doi.org/10.1176/appi.ajp.2019.19010091
Preview Abstract
The transition from childhood to adulthood represents the developmental time frame in which the majority of psychiatric disorders emerge. Recent efforts to identify risk factors mediating the susceptibility to psychopathology have led to a heightened ...
Articles
AudioCME
March 2019Adolescents Who Self-Harm and Commit Violent Crime: Testing Early-Life Predictors of Dual Harm in a Longitudinal Cohort Study
- Leah S. Richmond-Rakerd,Ph.D.,
- Avshalom Caspi,Ph.D.,
- Louise Arseneault,Ph.D.,
- Jessie R. Baldwin,Ph.D.,
- Andrea Danese,M.D.,Ph.D.,
- Renate M. Houts,Ph.D.,
- Timothy Matthews,Ph.D.,
- Jasmin Wertz,Ph.D.,
- Terrie E. Moffitt,Ph.D.
- Pages:186–195
- Published Online:4 January 2019
https://doi.org/10.1176/appi.ajp.2018.18060740
Preview Abstract
Objective:Self-harm is associated with violent offending. However, little is known about young people who engage in “dual-harm” behavior. The authors investigated antecedents, clinical features, and life characteristics distinguishing dual-harming ...
VideoCME
March 2019Age-Associated Deviations of Amygdala Functional Connectivity in Youths With Psychosis Spectrum Disorders: Relevance to Psychotic Symptoms
- Maria Jalbrzikowski,Ph.D.,
- Vishnu P. Murty,Ph.D.,
- Brenden Tervo-Clemmens,M.S.,
- William Foran,M.S.,
- Beatriz Luna,Ph.D.
- Pages:196–207
- Published Online:18 January 2019
https://doi.org/10.1176/appi.ajp.2018.18040443
Preview Abstract
Objective:The authors created normative growth charts of amygdala functional connectivity in typically developing youths, assessed age-associated deviations of these trajectories in youths with psychosis spectrum disorders, and explored how these ...
March 2019
Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls
- Do P.M. Tromp,Ph.D.,
- Lisa E. Williams,Ph.D.,
- Andrew S. Fox,Ph.D.,
- Jonathan A. Oler,Ph.D.,
- Patrick H. Roseboom,Ph.D.,
- Gregory M. Rogers,Ph.D.,
- Brenda E. Benson,Ph.D.,
- Andrew L. Alexander,Ph.D.,
- Daniel S. Pine,M.D.,
- Ned H. Kalin,M.D.
- Pages:208–216
- Published Online:18 January 2019
https://doi.org/10.1176/appi.ajp.2018.18040425
Preview Abstract
Objective:Anxiety disorders are common, can result in lifelong suffering, and frequently begin before adolescence. Evidence from adults suggests that altered prefrontal-limbic connectivity is a pathophysiological feature of anxiety disorders. More ...
March 2019
Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies
- Dongmei Yu,M.S.,
- Jae Hoon Sul,Ph.D.,
- Fotis Tsetsos,Ph.D.,
- Muhammad S. Nawaz,Ph.D.,
- Alden Y. Huang,Ph.D.,
- Ivette Zelaya,Ph.D.,
- Cornelia Illmann,Ph.D.,
- Lisa Osiecki,B.A.,
- Sabrina M. Darrow,Ph.D.,
- Matthew E. Hirschtritt,M.D.,M.P.H.,
- Erica Greenberg,M.D.,
- Kirsten R. Muller-Vahl,M.D.,
- Manfred Stuhrmann,M.D.,
- Yves Dion,M.D.,
- Guy Rouleau,M.D.,
- Harald Aschauer,M.D.,
- Mara Stamenkovic,M.D.,
- Monika Schlögelhofer,M.A.,
- Paul Sandor,M.D.,
- Cathy L. Barr,Ph.D.,
- Marco Grados,M.D.,M.P.H.,
- Harvey S. Singer,M.D.,
- Markus M. Nöthen,M.D.,
- Johannes Hebebrand,M.D.,
- Anke Hinney,Ph.D.,
- Robert A. King,M.D.,
- Thomas V. Fernandez,M.D.,Ph.D.,
- Csaba Barta,Ph.D.,
- Zsanett Tarnok,Ph.D.,
- Peter Nagy,M.D.,
- Christel Depienne,Ph.D.,
- Yulia Worbe,M.D.,Ph.D.,
- Andreas Hartmann,M.D.,
- Cathy L. Budman,M.D.,
- Renata Rizzo,M.D.,Ph.D.,
- Gholson J. Lyon,M.D.,Ph.D.,
- William M. McMahon,M.D.,
- James R. Batterson,M.D.,
- Danielle C. Cath,M.D.,
- Irene A. Malaty,M.D.,
- Michael S. Okun,M.D.,
- Cheston Berlin,M.D.,
- Douglas W. Woods,Ph.D.,
- Paul C. Lee,M.D.,M.P.H.,
- Joseph Jankovic,M.D.,
- Mary M. Robertson,M.D.,Ph.D.,
- Donald L. Gilbert,M.D.,
- Lawrence W. Brown,M.D.,
- Barbara J. Coffey,M.D.,
- Andrea Dietrich,Ph.D.,
- Pieter J. Hoekstra,M.D.,Ph.D.,
- Samuel Kuperman,M.D.,
- Samuel H. Zinner,M.D.,
- Pétur Luðvigsson,M.D.,
- Evald Sæmundsen,M.D.,
- Ólafur Thorarensen,M.D.,
- Gil Atzmon,Ph.D.,
- Nir Barzilai,M.D.,
- Michael Wagner,Ph.D.,
- Rainald Moessner,M.D.,
- Roel Ophoff,Ph.D.,
- Carlos N. Pato,M.D.,Ph.D.,
- Michele T. Pato,M.D.,
- James A. Knowles,M.D.,Ph.D.,
- Joshua L. Roffman,M.D.,
- Jordan W. Smoller,M.D.,Sc.D.,
- Randy L. Buckner,Ph.D.,
- A. Jeremy Willsey,Ph.D.,
- Jay A. Tischfield,Ph.D.,
- Gary A. Heiman,Ph.D.,
- Hreinn Stefansson,Ph.D.,
- Kári Stefansson,M.D.,
- Danielle Posthuma,Ph.D.,
- Nancy J. Cox,Ph.D.,
- David L. Pauls,Ph.D.,
- Nelson B. Freimer,M.D.,
- Benjamin M. Neale,Ph.D.,
- Lea K. Davis,Ph.D.,
- Peristera Paschou,Ph.D.,
- Giovanni Coppola,M.D.,
- Carol A. Mathews,M.D.,
- Jeremiah M. Scharf,M.D.,Ph.D.,
- on behalf of the Tourette Association of America International Consortium for Genetics, the Gilles de la Tourette GWAS Replication Initiative, the Tourette International Collaborative Genetics Study, and the Psychiatric Genomics Consortium Tourette Syndrome Working Group
- Pages:217–227
- Published Online:1 March 2019
https://doi.org/10.1176/appi.ajp.2018.18070857
Preview Abstract
Objective:Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted a ...
March 2019
Genetic Markers of ADHD-Related Variations in Intracranial Volume
- Marieke Klein,M.Sc.,
- Raymond K. Walters,Ph.D.,
- Ditte Demontis,Ph.D.,
- Jason L. Stein,Ph.D.,
- Derrek P. Hibar,Ph.D.,
- Hieab H. Adams,Ph.D.,
- Janita Bralten,Ph.D.,
- Nina Roth Mota,Ph.D.,
- Russell Schachar,M.D.,Ph.D.,
- Edmund Sonuga-Barke,Ph.D.,
- Manuel Mattheisen,M.D.,
- Benjamin M. Neale,Ph.D.,
- Paul M. Thompson,Ph.D.,
- Sarah E. Medland,Ph.D.,
- Anders D. Børglum,M.D.,Ph.D.,
- Stephen V. Faraone,Ph.D.,
- Alejandro Arias-Vasquez,Ph.D.,
- Barbara Franke,Ph.D.
- Pages:228–238
- Published Online:1 March 2019
https://doi.org/10.1176/appi.ajp.2018.18020149
Preview Abstract
Objective:Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, ...
Video
March 2019A Contagion Model for Within-Family Transmission of Drug Abuse
- Kenneth S. Kendler,M.D.,
- Henrik Ohlsson,Ph.D.,
- Jan Sundquist,M.D., Ph.D.,
- Kristina Sundquist,M.D., Ph.D.
- Pages:239–248
- Published Online:1 March 2019
https://doi.org/10.1176/appi.ajp.2018.18060637
Preview Abstract
Objective:The purpose of this study was to determine whether, controlling for genetic effects, drug abuse was transmitted within families as predicted by a contagion model.Methods:The authors examined 65,006 parent-offspring, sibling, and cousin pairs ...
Letters to the Editor
March 2019
Caution Against Overinterpreting Opiate Receptor Stimulation as Mediating Antidepressant Effects of Ketamine
- Gerard Sanacora,M.D., Ph.D.
- Page:249
- Published Online:1 March 2019
March 2019
Interpreting Ketamine’s Opioid Receptor Dependent Effect: Response to Sanacora
- Boris D. Heifets,M.D., Ph.D.,
- Nolan R. Williams,M.D.,
- Christine Blasey,Ph.D.,
- Keith Sudheimer,Ph.D.,
- Carolyn I. Rodriguez,M.D., Ph.D.,
- Alan F. Schatzberg,M.D.
- Pages:249–250
- Published Online:1 March 2019
March 2019
Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism: Is It a Ketamine-Specific Effect?
- Revital Amiaz,M.D.
- Pages:250–251
- Published Online:1 March 2019
March 2019
Target Population, Dose, and Timing Considerations for Understanding Naltrexone’s Subjective Effect: Response to Amiaz
- Boris D. Heifets,M.D., Ph.D.,
- Nolan R. Williams,M.D.,
- Christine Blasey,Ph.D.,
- Keith Sudheimer,Ph.D.,
- Carolyn I. Rodriguez,M.D., Ph.D.,
- Alan F. Schatzberg,M.D.
- Pages:251–252
- Published Online:1 March 2019