American Journal of Psychiatry
Volume 176, Issue 2
February 2019
Cover: Positive and negative abstinence networks based on connectivity betweenmacroscale brain regions from the article by Yip et al. in this issue exploring predictionof cocaine abstinence (p. 156).
Editor’s Note
February 2019
New Findings Relevant to Substance Use Disorders
- Ned H. Kalin,M.D.
- Page:A10
- Published Online:1 February 2019
Editorials
Audio
February 2019Improving Our Understanding of Substance Use Disorders
- Kathleen T. Brady,M.D.,Ph.D.
- Pages:87–89
- Published Online:1 February 2019
February 2019
Smoking Cannabis and Acquired Impairments in Cognition: Starting Early Seems Like a Really Bad Idea
- Philip D. Harvey,Ph.D.
- Pages:90–91
- Published Online:1 February 2019
February 2019
Phenotype and Environment Matter: Discovering the Genetic and Epigenetic Architecture of Alcohol Use Disorders
- Jonathan D. Pollock,Ph.D.,
- Amy C. Lossie,Ph.D.
- Pages:92–95
- Published Online:1 February 2019
Perspectives in Global Mental Health
February 2019
Psychiatric Research in North Korea in the 21st Century
- Seon-Cheol Park,M.D., Ph.D.,
- Joonho Choi,M.D., Ph.D.,
- Dong-Woo Lee,M.D., Ph.D.,
- Yong Chon Park,M.D., Ph.D.
- Pages:96–97
- Published Online:1 February 2019
Articles
AudioCME
February 2019A Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development
- Jean-François G. Morin,B.A.,
- Mohammad H. Afzali,Ph.D.,
- Josiane Bourque,M.Sc.,
- Sherry H. Stewart,Ph.D.,
- Jean R. Séguin,Ph.D.,
- Maeve O’Leary-Barrett,Ph.D.,
- Patricia J. Conrod,Ph.D.
- Pages:98–106
- Published Online:3 October 2018
https://doi.org/10.1176/appi.ajp.2018.18020202
Preview Abstract
Objective:Alcohol and cannabis misuse are related to impaired cognition. When inferring causality, four nonexclusive theoretical models can account for this association: 1) a common underlying vulnerability model; 2) a neuroplasticity model in which ...
Audio
February 2019Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts
- Sandra Sanchez-Roige,Ph.D.,
- Abraham A. Palmer,Ph.D.,
- Pierre Fontanillas,Ph.D.,
- Sarah L. Elson,Ph.D.,
- the 23andMe Research Team, the Substance Use Disorder Working Group of the Psychiatric Genomics Consortium,
- Mark J. Adams,Ph.D.,
- David M. Howard,Ph.D.,
- Howard J. Edenberg,Ph.D.,
- Gail Davies,Ph.D.,
- Richard C. Crist,Ph.D.,
- Ian J. Deary,Ph.D.,M.R.C.Psych.,
- Andrew M. McIntosh,M.D.,
- Toni-Kim Clarke,Ph.D.
- Pages:107–118
- Published Online:19 October 2018
https://doi.org/10.1176/appi.ajp.2018.18040369
Preview Abstract
Objective:Alcohol use disorders are common conditions that have enormous social and economic consequences. Genome-wide association analyses were performed to identify genetic variants associated with a proxy measure of alcohol consumption and alcohol ...
AudioVideo
February 2019Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects
- Scott Mackey,Ph.D.,
- Nicholas Allgaier,Ph.D.,
- Bader Chaarani,Ph.D.,
- Philip Spechler,B.A.,
- Catherine Orr,Ph.D.,
- Janice Bunn,Ph.D.,
- Nicholas B. Allen,Ph.D.,
- Nelly Alia-Klein,Ph.D.,
- Albert Batalla,M.D.,Ph.D.,
- Sara Blaine,Ph.D.,
- Samantha Brooks,Ph.D.,
- Elisabeth Caparelli,Ph.D.,
- Yann Ying Chye,Ph.D.,
- Janna Cousijn,Ph.D.,
- Alain Dagher,M.D.,
- Sylvane Desrivieres,Ph.D.,
- Sarah Feldstein-Ewing,Ph.D.,
- John J. Foxe,Ph.D.,
- Rita Z. Goldstein,Ph.D.,
- Anna E. Goudriaan,Ph.D.,
- Mary M. Heitzeg,Ph.D.,
- Robert Hester,Ph.D.,
- Kent Hutchison,Ph.D.,
- Ozlem Korucuoglu,Ph.D.,
- Chiang-Shan R. Li,M.D.,Ph.D.,
- Edythe London,Ph.D.,
- Valentina Lorenzetti,Ph.D.,
- Maartje Luijten,Ph.D.,
- Rocio Martin-Santos,M.D.,
- April May,M.A.,
- Reza Momenan,M.D.,
- Angelica Morales,Ph.D.,
- Martin P. Paulus,M.D.,
- Godfrey Pearlson,M.A.,M.B.B.S.,
- Marc-Etienne Rousseau,M.Sc.,
- Betty Jo Salmeron,M.D.,
- Renée Schluter,Ph.D.,
- Lianne Schmaal,Ph.D.,
- Gunter Schumann,M.D.,Ph.D.,
- Zsuzsika Sjoerds,Ph.D.,
- Dan J. Stein,Ph.D.,
- Elliot A. Stein,Ph.D.,
- Rajita Sinha,Ph.D.,
- Nadia Solowij,Ph.D.,
- Susan Tapert,Ph.D.,
- Anne Uhlmann,Ph.D.,
- Dick Veltman,M.D.,Ph.D.,
- Ruth van Holst,Ph.D.,
- Sarah Whittle,Ph.D.,
- Margaret J. Wright,Ph.D.,
- Murat Yücel,Ph.D.,
- Sheng Zhang,Ph.D.,
- Deborah Yurgelun-Todd,Ph.D.,
- Derrek P. Hibar,Ph.D.,
- Neda Jahanshad,Ph.D.,
- Alan Evans,Ph.D.,
- Paul M. Thompson,Ph.D.,
- David C. Glahn,Ph.D.,
- Patricia Conrod,Ph.D.,
- Hugh Garavan,Ph.D.,
- the ENIGMA Addiction Working Group
- Pages:119–128
- Published Online:19 October 2018
https://doi.org/10.1176/appi.ajp.2018.17040415
Preview Abstract
Objective:Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is ...
Audio
February 2019A Randomized Trial Comparing Extended-Release Injectable Suspension and Oral Naltrexone, Both Combined With Behavioral Therapy, for the Treatment of Opioid Use Disorder
- Maria A. Sullivan,M.D.,Ph.D.,
- Adam Bisaga,M.D.,
- Martina Pavlicova,Ph.D.,
- Kenneth M. Carpenter,Ph.D.,
- C. Jean Choi,M.S.,
- Kaitlyn Mishlen,M.A.,
- Frances R. Levin,M.D.,
- John J. Mariani,M.D.,
- Edward V. Nunes,M.D.
- Pages:129–137
- Published Online:19 October 2018
https://doi.org/10.1176/appi.ajp.2018.17070732
Preview Abstract
Objective:The oral formulation of the opioid antagonist naltrexone has shown limited effectiveness for treatment of opioid use disorder due to poor adherence. Long-acting injection naltrexone (XR-naltrexone), administered monthly, circumvents the need for ...
AudioCME
February 2019Protective Effects of Pregnancy on Risk of Alcohol Use Disorder
- Alexis C. Edwards,Ph.D.,
- Henrik Ohlsson,Ph.D.,
- Dace S. Svikis,Ph.D.,
- Jan Sundquist,M.D.,Ph.D.,
- Kristina Sundquist,M.D.,Ph.D.,
- Kenneth S. Kendler,M.D.
- Pages:138–145
- Published Online:29 November 2018
https://doi.org/10.1176/appi.ajp.2018.18050632
Preview Abstract
Objective:The authors sought to clarify the etiology of the association between pregnancy and reduced risk of alcohol use disorder.Methods:The authors used data from longitudinal population-wide Swedish medical, pharmacy, and criminal registries to ...
Audio
February 2019Allele-Specific Methylation ofSPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse
- Nicole Tay,M.Sc.,
- Christine Macare,Ph.D.,
- Yun Liu,Ph.D.,
- Barbara Ruggeri,Ph.D.,
- Tianye Jia,Ph.D.,
- Congying Chu,Ph.D.,
- Francesca Biondo,Ph.D.,
- Alex Ing,Ph.D.,
- Qiang Luo,Ph.D.,
- Daniil Sarkysian,Ph.D.,
- Tobias Banaschewski,M.D.,Ph.D.,
- Gareth J. Barker,Ph.D.,
- Arun L.W. Bokde,Ph.D.,
- Uli Bromberg,Ph.D.,
- Christian Büchel,M.D.,
- Erin Burke Quinlan,Ph.D.,
- Sylvane Desrivières,Ph.D.,
- Herta Flor,Ph.D.,
- Vincent Frouin,Ph.D.,
- Hugh Garavan,Ph.D.,
- Penny Gowland,Ph.D.,
- Andreas Heinz,M.D.,Ph.D.,
- Bernd Ittermann,Ph.D.,
- Jean-Luc Martinot,M.D.,Ph.D.,
- Eric Artiges,M.D.,Ph.D.,
- Frauke Nees,Ph.D.,
- Dimitri Papadopoulos Orfanos,Ph.D.,
- Tomáš Paus,M.D.,Ph.D.,
- Luise Poustka,M.D.,
- Sarah Hohmann,M.D.,
- Juliane H. Fröhner,M.Sc.,
- Michael N. Smolka,M.D.,
- Henrik Walter,M.D.,Ph.D.,
- Robert Whelan,Ph.D.,
- Helge Frieling,M.D.,Ph.D.,
- Stefan Bleich,M.D.,Ph.D.,
- Edward D. Barker,Ph.D.,
- Ann-Christine Syvänen,Ph.D.,
- Joëlle Rüegg,Ph.D.,
- Tomas J. Ekström,Ph.D.,
- Georgy Bakalkin,Ph.D.,
- Gunter Schumann,M.D., and
- the IMAGEN Consortium
- Pages:146–155
- Published Online:11 December 2018
https://doi.org/10.1176/appi.ajp.2018.17121360
Preview Abstract
Objective:Psychosocial stress is a key risk factor for substance abuse among adolescents. Recently, epigenetic processes such as DNA methylation have emerged as potential mechanisms that could mediate this relationship. The authors conducted a genome-wide ...
AudioVideoCME
February 2019Connectome-Based Prediction of Cocaine Abstinence
- Sarah W. Yip,Ph.D.,M.Sc.,
- Dustin Scheinost,Ph.D.,
- Marc N. Potenza,M.D.,Ph.D.,
- Kathleen M. Carroll,Ph.D.
- Pages:156–164
- Published Online:4 January 2019
https://doi.org/10.1176/appi.ajp.2018.17101147
Preview Abstract
Objective:The authors sought to identify a brain-based predictor of cocaine abstinence by using connectome-based predictive modeling (CPM), a recently developed machine learning approach. CPM is a predictive tool and a method of identifying networks that ...
Letters to the Editor
February 2019
Prazosin and Alcohol Use Disorder
- Robert Andrew Kleinman,M.D.,
- Michael J. Ostacher,M.D., M.P.H.
- Page:165
- Published Online:1 February 2019
February 2019
Prazosin for Alcohol Use Disorder: Response to Kleinman and Ostacher
- Tracy L. Simpson,Ph.D.
- Andrew J. Saxon,M.D.
- Murray Raskind,M.D.
- Pages:165–166
- Published Online:1 February 2019