Standard treatments for bulimia nervosa are for patients with normal weight, but a growing proportion of patients are substantially overweight or obese. Weight-related medical problems require coordination with primary care and expanded treatment goals. ...

Images in Psychiatry

October 2012

The Massachusetts Mental Health Center: Going Forward After 100 Years

Page:1037
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.12030362

Reviews and Overviews

October 2012

Toward Systems Neuroscience of ADHD: A Meta-Analysis of 55 fMRI Studies

Pages:1038–1055
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.11101521

Preview Abstract

ObjectiveThe authors performed a comprehensive meta-analysis of task-based functional MRI studies of attention deficit hyperactivity disorder (ADHD).MethodThe authors searched PubMed, Ovid, EMBASE, Web of Science, ERIC, CINAHAL, and NeuroSynth for studies ...

Articles

October 2012

Application of DSM-5 Criteria for Autism Spectrum Disorder to Three Samples of Children With DSM-IV Diagnoses of Pervasive Developmental Disorders

Pages:1056–1064
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.12020276

Preview Abstract

Applying the latest proposed DSM-5 criteria for autism spectrum disorder (ASD) to parent-reported symptoms yielded an ASD diagnosis for 91% of 4,453 children previously given DSM-IV clinical diagnoses of pervasive developmental disorders (PDDs)—autistic ...

October 2012

Antidepressant Response in Patients With Major Depression Exposed to NSAIDs: A Pharmacovigilance Study

Pages:1065–1072
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.11091325

Preview Abstract

Coexisting general medical illness accounts for much of the previously reported association between use of nonsteroidal anti-inflammatory drugs (NSAIDs) and nonremission of treated depression. A modest but smaller relationship for NSAIDs remained when ...

October 2012

Decline in Genetic Influence on the Co-Occurrence of Alcohol, Marijuana, and Nicotine Dependence Symptoms From Age 14 to 29

Pages:1073–1081
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.11081268

Preview Abstract

ObjectiveCross-sectional studies have demonstrated high rates of comorbidity among substance use disorders. However, few studies have examined the developmental course of incident comorbidity and how it changes from adolescence to adulthood. The authors ...

October 2012

Deficits in Transcriptional Regulators of Cortical Parvalbumin Neurons in Schizophrenia

David W. Volk,M.D., Ph.D.,
Takurou Matsubara,M.D.,
Siyu Li,M.A.,
Elizabeth J. Sengupta,M.A.,
Danko Georgiev,M.D., Ph.D.,
Yoshio Minabe,M.D., Ph.D.,
Allan Sampson,Ph.D.,
Takanori Hashimoto,M.D., Ph.D., and
David A. Lewis,M.D.

Pages:1082–1091
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.12030305

Preview Abstract

ObjectiveIn schizophrenia, alterations within the prefrontal cortical GABA system appear to be most prominent in neurons that contain parvalbumin or somatostatin but not calretinin. The transcription factors Lhx6 and Sox6 play critical roles in the ...

October 2012

Thalamocortical Dysconnectivity in Schizophrenia

Pages:1092–1099
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.12010056

Preview Abstract

ObjectiveThe thalamus and cerebral cortex are connected via topographically organized, reciprocal connections. Previous studies have revealed thalamic abnormalities in schizophrenia; however, it is not known whether thalamocortical networks are ...

October 2012

Presupplementary Motor Area Hyperactivity During Response Inhibition: A Candidate Endophenotype of Obsessive-Compulsive Disorder

Pages:1100–1108
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.12010073

Preview Abstract

ObjectiveEndophenotype studies of obsessive-compulsive disorder (OCD) may uncover heritable traits that are related to genetic susceptibility to OCD. Deficient response inhibition is a promising endophenotype of OCD, although its functional neural ...

October 2012

Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits

Pages:1109–1116
Published Online:1 October 2012

https://doi.org/10.1176/appi.ajp.2012.12020191

Preview Abstract

ObjectiveIn children with conduct problems, high levels of callous-unemotional traits are associated with amygdala hypoactivity to consciously perceived fear, while low levels of callous-unemotional traits may be associated with amygdala hyperactivity. ...