American Journal of Psychiatry
Volume 175, Issue 5
May 2018
Cover: Brunet et al. (p. 427) investigated administration of propranolol before memory reactivation during therapy for PTSD. Their aim was to impede reconsolidation of traumatic memories. [Image by StockPhotosLV, Shutterstock.com.]
Editorials
May 2018
Eradicating Traumatic Memories: Implications for PTSD Treatment
- Matthew J. Friedman,M.D., Ph.D.
- Pages:391–392
- Published Online:1 May 2018
May 2018
Toward Dissemination of Secondary Prevention for Psychosis
- Robert Rosenheck,M.D.
- Pages:393–394
- Published Online:1 May 2018
May 2018
Mindful Pharmacogenetics: Drug Dosing for Mental Health
- Julia C. Stingl,M.D.
- Pages:395–397
- Published Online:1 May 2018
May 2018
A Role for Placental CRH in Cortical Thinning and Neuropsychiatric Outcomes
- Megan R. Gunnar,Ph.D.
- Pages:398–399
- Published Online:1 May 2018
Clinical Case Conference
AudioCME
May 2018Developmental Delay, Treatment-Resistant Psychosis, and Early-Onset Dementia in a Man With 22q11 Deletion Syndrome and Huntington’s Disease
- Martilias Farrell,Ph.D.,
- Maya Lichtenstein,M.D.,
- James J. Crowley,Ph.D.,
- Dawn M. Filmyer,Ph.D.,
- Gabriel Lázaro-Muñoz,J.D., Ph.D.,
- Rita A. Shaughnessy,M.D., Ph.D.,
- Ian R. Mackenzie,M.D., F.R.C.P.C.,
- Veronica Hirsch-Reinshagen,M.D.,
- Robert Stowe,M.D.,
- James P. Evans,M.D., Ph.D.,
- Jonathan S. Berg,M.D., Ph.D.,
- Jin Szatkiewicz,Ph.D.,
- Richard C. Josiassen,Ph.D.,
- Patrick F. Sullivan,M.D., F.R.A.N.Z.C.P.
- Pages:400–407
- Published Online:1 May 2018
Perspectives in Global Mental Health
May 2018
Failure to Identify a Human Trafficking Victim
- Mollie Gordon,M.D.,
- Shelley Fang,B.S., B.S.A.,
- John Coverdale,M.D., M.Ed.,
- Phuong Nguyen,Ph.D.
- Pages:408–409
- Published Online:1 May 2018
Images in Psychiatry
May 2018
Addressing the Homeless Mentally Ill in San Francisco
- Ira D. Glick,M.D.
- Page:410
- Published Online:1 May 2018
Reviews and Overviews
Audio
May 2018Early Intervention in Bipolar Disorder
- Eduard Vieta,M.D., Ph.D.,
- Estela Salagre,M.D.,
- Iria Grande,M.D., Ph.D.,
- André F. Carvalho,M.D., Ph.D.,
- Brisa S. Fernandes,M.D., Ph.D.,
- Michael Berk,M.D., Ph.D.,
- Boris Birmaher,M.D.,
- Mauricio Tohen,M.D., Dr.P.H.,
- Trisha Suppes,M.D., Ph.D.
- Pages:411–426
- Published Online:24 January 2018
https://doi.org/10.1176/appi.ajp.2017.17090972
Preview Abstract
Bipolar disorder is a recurrent disorder that affects more than 1% of the world population and usually has its onset during youth. Its chronic course is associated with high rates of morbidity and mortality, making bipolar disorder one of the main causes ...
Articles
AudioVideoCME
May 2018Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial
- Alain Brunet,Ph.D.,
- Daniel Saumier,Ph.D.,
- Aihua Liu,Ph.D.,
- David L. Streiner,Ph.D.,
- Jacques Tremblay,M.D.,
- Roger K. Pitman,M.D.
- Pages:427–433
- Published Online:12 January 2018
https://doi.org/10.1176/appi.ajp.2017.17050481
Preview Abstract
Objective:The authors assessed the efficacy of trauma memory reactivation performed under the influence of propranolol, a noradrenergic beta-receptor blocker, as a putative reconsolidation blocker, in reducing symptoms of posttraumatic stress disorder (...
Audio
May 2018Care Pathways Before First Diagnosis of a Psychotic Disorder in Adolescents and Young Adults
- Gregory E. Simon,M.D., M.P.H.,
- Christine Stewart,Ph.D.,
- Enid M. Hunkeler,M.A.,
- Bobbi Jo Yarborough,Ph.D.,
- Frances Lynch,Ph.D.,
- Karen J. Coleman,Ph.D.,
- Arne Beck,Ph.D.,
- Belinda H. Operskalski,M.P.H.,
- Robert B. Penfold,Ph.D.,
- David S. Carrell,Ph.D.
- Pages:434–442
- Published Online:24 January 2018
https://doi.org/10.1176/appi.ajp.2017.17080844
Preview Abstract
Objective:The authors sought to describe patterns of health care use prior to first diagnosis of a psychotic disorder in a population-based sample.Method:Electronic health records and insurance claims from five large integrated health systems were used to ...
AudioCME
May 2018Effectiveness of Early Psychosis Intervention: Comparison of Service Users and Nonusers in Population-Based Health Administrative Data
- Kelly K. Anderson,Ph.D.,
- Ross Norman,Ph.D.,
- Arlene MacDougall,M.D., M.Sc.,
- Jordan Edwards,M.Sc.,
- Lena Palaniyappan,M.D., Ph.D.,
- Cindy Lau,M.Sc.,
- Paul Kurdyak,M.D., Ph.D.
- Pages:443–452
- Published Online:2 March 2018
https://doi.org/10.1176/appi.ajp.2017.17050480
Preview Abstract
Objective:Early psychosis intervention (EPI) programs improve clinical and functional outcomes for people with first-episode psychosis. Less is known about the impact of these programs on the larger health care system. The authors sought to compare ...
May 2018
Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
- Premika S.W. Boedhoe,M.Sc.,
- Lianne Schmaal,Ph.D.,
- Yoshinari Abe,M.D.,
- Pino Alonso,M.D., Ph.D.,
- Stephanie H. Ameis,M.D., M.Sc.,
- Alan Anticevic,Ph.D.,
- Paul D. Arnold,M.D., Ph.D.,
- Marcelo C. Batistuzzo,Ph.D.,
- Francesco Benedetti,M.D.,
- Jan C. Beucke,Ph.D.,
- Irene Bollettini,Ph.D.,
- Anushree Bose,M.A.,
- Silvia Brem,Ph.D.,
- Anna Calvo,M.Sc.,
- Rosa Calvo,M.D., Ph.D.,
- Yuqi Cheng,Ph.D.,
- Kang Ik K. Cho,Ph.D.,
- Valentina Ciullo,Ph.D.,
- Sara Dallaspezia,M.D.,
- Damiaan Denys,M.D., Ph.D.,
- Jamie D. Feusner,M.D.,
- Kate D. Fitzgerald,M.D.,
- Jean-Paul Fouche,Ph.D.,
- Egill A. Fridgeirsson,M.Sc.,
- Patricia Gruner,Ph.D.,
- Gregory L. Hanna,M.D.,
- Derrek P. Hibar,Ph.D.,
- Marcelo Q. Hoexter,M.D., Ph.D.,
- Hao Hu,Ph.D.,
- Chaim Huyser,M.D., Ph.D.,
- Neda Jahanshad,Ph.D.,
- Anthony James,M.D.,
- Norbert Kathmann,Ph.D.,
- Christian Kaufmann,Ph.D.,
- Kathrin Koch,Ph.D.,
- Jun Soo Kwon,M.D., Ph.D.,
- Luisa Lazaro,M.D., Ph.D.,
- Christine Lochner,Ph.D.,
- Rachel Marsh,Ph.D.,
- Ignacio Martínez-Zalacaín,M.Sc.,
- David Mataix-Cols,Ph.D.,
- José M. Menchón,M.D., Ph.D.,
- Luciano Minuzzi,M.D., Ph.D.,
- Astrid Morer,M.D., Ph.D.,
- Takashi Nakamae,M.D., Ph.D.,
- Tomohiro Nakao,M.D., Ph.D.,
- Janardhanan C. Narayanaswamy,M.D.,
- Seiji Nishida,M.D., Ph.D.,
- Erika Nurmi,M.D., Ph.D.,
- Joseph O’Neill,Ph.D.,
- John Piacentini,Ph.D.,
- Fabrizio Piras,Ph.D.,
- Federica Piras,Ph.D.,
- Y.C. Janardhan Reddy,M.D.,
- Tim J. Reess,M.A.,
- Yuki Sakai,M.D., Ph.D.,
- Joao R. Sato,Ph.D.,
- H. Blair Simpson,M.D., Ph.D.,
- Noam Soreni,M.D.,
- Carles Soriano-Mas,Ph.D.,
- Gianfranco Spalletta,M.D., Ph.D.,
- Michael C. Stevens,Ph.D.,
- Philip R. Szeszko,Ph.D.,
- David F. Tolin,Ph.D.,
- Guido A. van Wingen,Ph.D.,
- Ganesan Venkatasubramanian,M.D., Ph.D.,
- Susanne Walitza,M.D., M.Sc.,
- Zhen Wang,M.D., Ph.D.,
- Je-Yeon Yun,M.D., Ph.D.,
- ENIGMA-OCD Working Group,
- Paul M. Thompson,Ph.D.,
- Dan J. Stein,M.D., Ph.D.,
- Odile A. van den Heuvel,M.D., Ph.D.
- Pages:453–462
- Published Online:15 December 2017
https://doi.org/10.1176/appi.ajp.2017.17050485
Preview Abstract
Objective:Brain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses ...
Video
May 2018Impact ofCYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients
- Marin M. Jukić,Ph.D.,
- Tore Haslemo,Ph.D.,
- Espen Molden,Ph.D.,
- Magnus Ingelman-Sundberg,Ph.D.
- Pages:463–470
- Published Online:12 January 2018
https://doi.org/10.1176/appi.ajp.2017.17050550
Preview Abstract
Objective:The antidepressant escitalopram is predominantly metabolized by the polymorphic CYP2C19 enzyme. The authors investigated the effect ofCYP2C19 genotype on exposure and therapeutic failure of escitalopram in a large patient population.Method:A ...
Video
May 2018Cortical Thinning and Neuropsychiatric Outcomes in Children Exposed to Prenatal Adversity: A Role for Placental CRH?
- Curt A. Sandman,Ph.D.,
- Megan M. Curran,B.S.,
- Elysia Poggi Davis,Ph.D.,
- Laura M. Glynn,Ph.D.,
- Kevin Head,B.S.,
- Tallie Z. Baram,M.D., Ph.D.
- Pages:471–479
- Published Online:2 March 2018
https://doi.org/10.1176/appi.ajp.2017.16121433
Preview Abstract
Objective:The authors sought to assess associations among early-life exposure to adversity, the development and maturation of neurons and brain circuits, and neurodevelopmental outcomes. Specifically, they examined whether fetal exposure to placental ...
Letters to the Editor
May 2018
Comment on Late-Onset ADHD Reconsidered With Comprehensive Repeated Assessments Between Ages 10 and 25
- Samuel R. Chamberlain,M.B.B.Chir. (Dr. Med.), Ph.D.,
- Ulrich Müller,M.D. (Dr. Med.), Ph.D.
- Page:480
- Published Online:1 May 2018
May 2018
The Importance of Scrutinizing Emergent ADHD Symptoms in Adults: Response to Chamberlain and Müller
- Margaret H. Sibley,Ph.D.,
- L. Eugene Arnold,M.D.,
- James M. Swanson,Ph.D.,
- Lily T. Hechtman,M.D.,
- John T. Mitchell,Ph.D.,
- Brooke S.G. Molina,Ph.D.,
- Traci M. Kennedy,Ph.D.,
- Arunima Roy,Ph.D.
- Pages:480–481
- Published Online:1 May 2018
May 2018
Late-Onset ADHD: Case Closed or Open Question?
- Jessica Agnew-Blais,Sc.D.,
- Louise Arseneault,Ph.D.
- Pages:481–482
- Published Online:1 May 2018
May 2018
Addressing Incomplete Psychiatric Histories in Adult ADHD: Response to Agnew-Blais and Arseneault
- Margaret H. Sibley,Ph.D.,
- L. Eugene Arnold,M.D.,
- James M. Swanson,Ph.D.,
- Traci M. Kennedy,Ph.D.,
- Brooke S.G. Molina,Ph.D.,
- Lily T. Hechtman,M.D.,
- Arunima Roy,Ph.D.,
- John T. Mitchell,Ph.D.
- Pages:482–483
- Published Online:1 May 2018
May 2018
Concerns Regarding the Proposed New Diagnosis of “Modern-Type Depression” in Japan
- Hisanobu Kaiya,M.D., Ph.D.
- Page:483
- Published Online:1 May 2018
May 2018
Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya
- Takahiro A. Kato,M.D., Ph.D.,
- Shigenobu Kanba,M.D., Ph.D.
- Pages:483–484
- Published Online:1 May 2018
Book Forum
May 2018
Foundations of Consultation-Liaison Psychiatry: The Bumpy Road to Specialization
- Alison Heru,M.D.
- Pages:485–486
- Published Online:1 May 2018