Objective: With recent advances in molecular genetics, the rate-limiting step in identifying susceptibility genes for psychiatric disorders has become phenotype definition. The success of psychiatric genetics may require the development of a “genetic ...

Objective: There has been considerable controversy regarding the impact of the Holocaust on the second generation, but few empirical data are available that systematically document trauma exposure and psychiatric disorder in these individuals. To obtain ...

Objective: The role of group therapy in treatment of posttraumatic stress disorder (PTSD) has been traditionally restricted to issues of self-esteem and interpersonal relationships, rather than primary symptoms of the disorder. In this study, the authors ...

Objective: This study was undertaken to clarify earlier inconsistent findings in brain metabolic topography in panic disorder patients at rest.Method: Positron emission tomography (PET) with [¹⁸F]fluorodeoxyglucose was used to determine cerebral metabolic ...

Objective: The authors investigated the role of genetic factors in 35% CO₂-induced panic attacks.Method: Ninety twins recruited from general population were challenged with one-vital capacity inhalations of 35% CO₂–65% O₂. Probandwise concordance rates ...

Objective: This study determined the efficacy and safety of sertraline in the treatment of patients with panic disorder. Method: The study was a randomized, double-blind, parallel-group, flexible-dose comparison of sertraline and placebo in outpatients ...

Objective: Many studies have validated the grouping of schizophrenic symptoms into three independent dimensions: negative, psychotic, and disorganized. Negative symptoms are considered to be an important prognostic indicator, but this clinical observation ...

Objective: This study investigated the rate of spontaneous abnormal involuntary movements in a group of patients presenting with a first episode of schizophrenia or schizophreniform psychosis. Method: Seventy-nine patients with a first episode of ...

Objective: Tardive dyskinesia is a movement disorder affecting 20%–40% of patients treated chronically with neuroleptic drugs. The dopamine supersensitivity hypothesis cannot account for the time course of tardive dyskinesia or for the persistence of ...

Objective: The authors investigated whether nonpsychotic relatives of schizophrenic probands have an elevated risk of deficits in sustained attention as measured by the Continuous Performance Test (CPT), whether such deficits are associated with specific ...

Objective: Patients with the deficit syndrome differ from other patients with schizophrenia relative to physiological correlates, course of illness, and response to treatment. Because of the abnormal seasonality of birth among persons with schizophrenia, ...

Objective: Study 1 evaluated whether pregnancy is a stressful life event for teenagers and is associated with depression for teenagers with a pessimistic attributional style but not for those with an optimistic attributional style. Study 2 replicated ...

Objective: While family and twin studies suggest that retrospectively reported premenstrual symptoms are heritable, these studies have not accounted for the unreliability of such measures. In addition, we know little about the relationship of the familial ...

Objective: Subnormal prolactin responses to the serotonin-releasing agonist fenfluramine occur in depression. Since many measures of serotonin pathology occur in depression, abnormal responses to fenfluramine may occur in brain structures other than the ...

Objective: The purpose of this study was to determine prospectively the optimal length of therapy in a long-term, placebo-controlled continuation study of patients who responded to acute fluoxetine treatment for major depression (defined by DSM-III-R). ...

Objective: The purpose of this study was to determine what predicts patients’ perceptions of coercion surrounding admission to a psychiatric hospital.Method: For 171 cases, the authors integrated data from interviews with patients, admitting clinicians, ...

Objective: This article brings to the present earlier bibliographies of books written by former mental patients. These books provide an inside view of mental disorder that can be useful in teaching, public education, theory, and research, and they have ...

Objective: The molecular basis of neuroleptic malignant syndrome is unclear, but studies suggest that genetic factors are involved in its pathogenesis. Considering possible involvement of the serotonergic system in neuroleptic malignant syndrome, the ...

Objective: The authors conducted a pilot study to develop preliminary data on the frequency of cytochrome P450-2D6 (CYP2D6) genotypes in state psychiatric hospital patients and to establish population sizes needed to determine potential clinical relevance ...

Objective: The mismatch negativity, a negative component in the auditory event-related potential, is thought to index automatic processes involved in sensory or echoic memory. The authors’ goal in this study was to examine the topography of auditory ...

Objective: Hypofrontality is a common but not invariable finding in schizophrenia. Inconsistencies in the literature may reflect, in part, the fact that abnormal physiological responses in the prefrontal cortex are best identified under conditions that ...

Objective: The authors’ goal was to compare the size and linear density of Purkinje cells in the cerebellar vermis of subjects with and without schizophrenia. Method: Blocks of alcohol-fixed cerebellar vermis were dissected at autopsy from the brains of ...