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Psychiatry Online
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Editorials
Perspectives in Global Mental Health
Clinical Case Conference
Images in Psychiatry
Reviews and Overviews
AudioMedical knowledge core competency
April 2017
Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis
  • Pages:319–328
  • Published Online:14 November 2016

https://doi.org/10.1176/appi.ajp.2016.16020138

Preview Abstract
The quality of fetal growth and development predicts the risk for a range of noncommunicable, chronic illnesses. These observations form the basis of the “developmental origins of health and disease” hypothesis, which suggests that the intrauterine ...
Articles
AudioVideo
April 2017
Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis
  • Pages:329–340
  • Published Online:14 November 2016

https://doi.org/10.1176/appi.ajp.2016.16030360

Preview Abstract
Objective:Previous meta-analyses indicate that computerized cognitive training (CCT) is a safe and efficacious intervention for cognition in older adults. However, efficacy varies across populations and cognitive domains, and little is known about the ...
AudioVideo
April 2017
The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder
  • Pages:341–348
  • Published Online:3 October 2016

https://doi.org/10.1176/appi.ajp.2016.16040467

Preview Abstract
Objective:The authors sought to determine the risk of treatment-emergent mania associated with methylphenidate, used in monotherapy or with a concomitant mood-stabilizing medication, in patients with bipolar disorder.Method:Using linked Swedish national ...
Audio
April 2017
The Origins of Cognitive Deficits in Victimized Children: Implications for Neuroscientists and Clinicians
  • Pages:349–361
  • Published Online:31 October 2016

https://doi.org/10.1176/appi.ajp.2016.16030333

Preview Abstract
Objective:Individuals reporting a history of childhood violence victimization have impaired brain function. However, the clinical significance, reproducibility, and causality of these findings are disputed. The authors used data from two large cohort ...
Audio
April 2017
Prediction of Relapse After Discontinuation of Antipsychotic Treatment in Alzheimer’s Disease: The Role of Hallucinations
  • Pages:362–369
  • Published Online:18 November 2016

https://doi.org/10.1176/appi.ajp.2016.16020226

Preview Abstract
Objective:In Alzheimer’s disease, antipsychotic medications are often used for a period, with relief of symptoms, and then discontinued, after which relapse may occur. The authors sought to determine which neuropsychiatric symptoms predict relapse.Method:...
Audio
April 2017
A Randomized Controlled Trial of Ethyl Glucuronide-Based Contingency Management for Outpatients With Co-Occurring Alcohol Use Disorders and Serious Mental Illness
  • Pages:370–377
  • Published Online:31 January 2017

https://doi.org/10.1176/appi.ajp.2016.16050627

Preview Abstract
Objective:The authors examined whether a contingency management intervention using the ethyl glucuronide (EtG) alcohol biomarker resulted in increased alcohol abstinence in outpatients with co-occurring serious mental illnesses. Secondary objectives were ...
April 2017
Dopaminergic Enhancement of Striatal Response to Reward in Major Depression
  • Pages:378–386
  • Published Online:24 October 2016

https://doi.org/10.1176/appi.ajp.2016.16010111

Preview Abstract
Objective:Major depressive disorder is characterized by reduced reward-related striatal activation and dysfunctional reward learning, putatively reflecting decreased dopaminergic signaling. The goal of this study was to test whether a pharmacological ...
April 2017
Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome
  • Pages:387–396
  • Published Online:4 November 2016

https://doi.org/10.1176/appi.ajp.2016.16020240

Preview Abstract
Objective:Phenotypic heterogeneity in Tourette syndrome is partly due to complex genetic relationships among Tourette syndrome, obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD). Identifying symptom-based ...
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