Objective:Women with a history of bipolar disorder, postpartum psychosis, or both are at high risk for postpartum relapse. The aim of this meta-analysis was to estimate the risk of postpartum relapse in these three patient groups.Method:A systematic ...

February 2016

The Sequential Integration of Pharmacotherapy and Psychotherapy in the Treatment of Major Depressive Disorder: A Meta-Analysis of the Sequential Model and a Critical Review of the Literature

Pages:128–137
Published Online:20 October 2015

https://doi.org/10.1176/appi.ajp.2015.15040476

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Objective:A number of randomized controlled trials in major depressive disorder have employed a sequential model, which consists of the use of pharmacotherapy in the acute phase and of psychotherapy in its residual phase. The aim of this review was to ...

Articles

February 2016

Defense Mechanisms of Pregnant Mothers Predict Attachment Security, Social-Emotional Competence, and Behavior Problems in Their Toddlers

Pages:138–146
Published Online:11 September 2015

https://doi.org/10.1176/appi.ajp.2015.15020173

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Objective:For at-risk (single parent, low income, low support) mothers, healthy adaptation and the ability to manage stress have clear implications for parenting and the social-emotional well-being of their young offspring. The purpose of this ...

February 2016

The Roles of Maternal Depression, Serotonin Reuptake Inhibitor Treatment, and Concomitant Benzodiazepine Use on Infant Neurobehavioral Functioning Over the First Postnatal Month

Pages:147–157
Published Online:30 October 2015

https://doi.org/10.1176/appi.ajp.2015.14080989

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Objective:The purpose of this article was to systematically compare the developmental trajectory of neurobehavior over the first postnatal month for infants with prenatal exposure to pharmacologically untreated maternal depression, selective serotonin ...

February 2016

Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression

Alexander Viktorin,M.Sc.,
Samantha Meltzer-Brody,M.D., M.P.H.,
Ralf Kuja-Halkola,Ph.D.,
Patrick F. Sullivan,M.D., F.R.A.N.Z.C.P.,
Mikael Landén,M.D., Ph.D.,
Paul Lichtenstein,Ph.D.,
Patrik K.E. Magnusson,Ph.D.

Pages:158–165
Published Online:4 September 2015

https://doi.org/10.1176/appi.ajp.2015.15010085

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Objective:The authors investigated the relative importance of genetic and environmental influences on perinatal depression, and the genetic overlap between perinatal depression and nonperinatal depression.Method:Analyses were conducted using structural ...

Video

February 2016

Comparative Effectiveness of Clozapine and Standard Antipsychotic Treatment in Adults With Schizophrenia

T. Scott Stroup,M.D., M.P.H.,
Tobias Gerhard,Ph.D.,
Stephen Crystal,Ph.D.,
Cecilia Huang,Ph.D.,
Mark Olfson,M.D., M.P.H.

Pages:166–173
Published Online:6 November 2015

https://doi.org/10.1176/appi.ajp.2015.15030332

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Objective:The authors compared the effectiveness of initiating treatment with either clozapine or a standard antipsychotic among adults with evidence of treatment-resistant schizophrenia in routine clinical practice.Method:U.S. national Medicaid data from ...

Video

February 2016

Systematic Review and Meta-Analysis: Dose-Response Relationship of Selective Serotonin Reuptake Inhibitors in Major Depressive Disorder

Pages:174–183
Published Online:10 November 2015

https://doi.org/10.1176/appi.ajp.2015.15030331

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Objective:Previous studies suggested that the treatment response to selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder follows a flat response curve within the therapeutic dose range. The present study was designed to clarify the ...

February 2016

Longitudinal Psychiatric Symptoms in Prodromal Huntington’s Disease: A Decade of Data

Eric A. Epping,M.D., Ph.D.,
Ji-In Kim,Ph.D.,
David Craufurd,M.B.B.S.,
Thomas M. Brashers-Krug,M.D., Ph.D.,
Karen E. Anderson,M.D.,
Elizabeth McCusker,M.B.B.S., F.R.A.C.P.,
Jolene Luther,B.A.,
Jeffrey D. Long,Ph.D.,
Jane S. Paulsen,Ph.D.;
PREDICT-HD Investigators and Coordinators of the Huntington Study Group

Pages:184–192
Published Online:16 October 2015

https://doi.org/10.1176/appi.ajp.2015.14121551

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Objective:Psychiatric symptoms are a significant aspect of Huntington’s disease, an inherited neurodegenerative illness. The presentation of these symptoms is highly variable, and their course does not fully correlate with motor or cognitive disease ...