OBJECTIVE: Over the past 3 years, reports of DNA alteration in myotonic dystrophy, fragile X syndrome (types A and E), Kennedy's disease, Huntington's disease, spinocerebellar ataxia type 1, and dentatorubral- pallidoluysian atrophy have identified a new ...

February 1995

D2 dopamine receptor occupancy during low-dose treatment with haloperidol decanoate

Pages:173–178
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.173

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OBJECTIVE: The aim of this study was to examine the relationships among clinical effects, central D2 dopamine receptor occupancy, and plasma concentrations of haloperidol in eight clinically stabilized schizophrenic outpatients who were responding to ...

February 1995

Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients

Pages:179–182
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.179

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OBJECTIVE: The purpose of this study was to determine if plasma clozapine levels were associated with treatment response. METHOD: To examine this question, neuroleptic nonresponsive patients with schizophrenia or schizoaffective disorder were given ...

February 1995

Reduction of suicidality during clozapine treatment of neuroleptic- resistant schizophrenia: impact on risk-benefit assessment

Pages:183–190
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.183

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OBJECTIVE: Suicide has been reported to occur in 9%-13% of schizophrenic patients. It has been suggested that neuroleptic- resistant or neuroleptic-intolerant schizophrenic patients are at higher risk for suicide than neuroleptic-responsive patients. ...

February 1995

Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects

Pages:191–196
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.191

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OBJECTIVE: The goal of this study was to assess neurological soft signs and developmental reflexes in schizophrenic patients who had never received neuroleptic medication and those who were receiving neuroleptic medication. METHOD: Neurological soft signs ...

February 1995

Severity of symptoms in chronically institutionalized geriatric schizophrenic patients

Pages:197–207
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.197

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OBJECTIVE: The goal of this study was to characterize the symptoms of geriatric, chronically ill, institutionalized schizophrenic patients and investigate age-related differences in schizophrenic symptoms and cognitive performance from early adulthood to ...

February 1995

Gender and age at onset in schizophrenia: impact of family history

Pages:208–212
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.208

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OBJECTIVE: The 1-year prevalence of schizophrenia was studied in a limited geographical area of Reunion Island (Indian Ocean) to assess the impact of family history of schizophrenia on the well-known association between gender and age at onset. METHOD: ...

February 1995

Brain potential evidence for an auditory sensory memory deficit in schizophrenia

Pages:213–219
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.213

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OBJECTIVE: The multiple disorders of selective attention found in schizophrenia could be secondary to disturbances in sensory processing. The authors investigated this possibility by using an event-related potential index of auditory sensory memory, ...

February 1995

Spurious precision: procedural validity of diagnostic assessment in psychotic disorders

Pages:220–223
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.220

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OBJECTIVE: Very few studies have quantified the level of agreement among alternative diagnostic procedures that use a common set of fixed operational criteria. The authors examined the procedural validity of four independent methods of assigning DSM-III-R ...

February 1995

Postictal and chronic psychoses in patients with temporal lobe epilepsy

Pages:224–231
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.224

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OBJECTIVE: This study sought to elucidate the relation of clinical, neuropsychological, and seizure variables to chronic and postictal psychoses in patients with temporal lobe epilepsy. METHOD: Forty-four patients with treatment-refractory temporal lobe ...

February 1995

Relationship between hypomania and personality disorders before and after successful treatment

Pages:232–238
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.232

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OBJECTIVE: To examine the effect of hypomanic states on maladaptive personality traits and personality disorders, the authors evaluated personality traits and disorders of patients during an episode of hypomania and after successful somatic treatment. ...

February 1995

DSM-III-R axis II comorbidity in dysthymia and major depression

Pages:239–247
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.239

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OBJECTIVE: Dysthymia is generally believed to be associated with a high rate of DSM-III-R axis II comorbidity. However, it is unclear whether this rate is higher than that for other axis I disorders, how many dysthymic patients have personality disorders, ...

February 1995

Delayed maturation of the frontal cortex in childhood autism

Pages:248–252
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.248

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OBJECTIVE: The authors investigated the metabolic maturation of the frontal cortex in pre-school autistic children. METHOD: Regional cerebral blood flow (CBF) in five children with primary autism diagnosed according to the DSM-III-R criteria was studied ...

February 1995

Changes in pathological narcissism

Pages:253–257
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.253

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OBJECTIVE: This study investigated types of change that occur over time in the psychopathology of narcissistic patients. METHOD: Baseline scores on the Diagnostic Interview for Narcissism of 20 patients, clinically diagnosed as having narcissistic ...

February 1995

Demographic and clinical comparison of obsessional followers and offenders with mental disorders

Pages:258–263
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.258

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OBJECTIVE: The purpose of this study was to compare certain demographic and clinical variables in a group of obsessional followers and in a group of offenders with mental disorders. METHOD: A static group design comprised of a nonrandom group of ...

Article

February 1995

Eliot Slater, 1904-1983

ROBIN M. MURRAY

Page:264
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.264

February 1995

Dexamethasone for the treatment of depression: a randomized, placebo- controlled, double-blind trial

Pages:265–267
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.265

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OBJECTIVE: The authors' goal was to assess dexamethasone for the treatment of depression. METHOD: Thirty-seven outpatients (11 men and 26 women) meeting DSM-III-R criteria for major depressive disorder were randomly assigned to receive either placebo or 4 ...

February 1995

Aspects of depression associated with borderline personality disorder

Pages:268–270
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.268

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OBJECTIVE: Shared symptoms between borderline personality disorder and depression have resulted in inherent difficulties in evaluating the relationship between these disorders. Some theorists have argued that depression in patients with borderline ...

February 1995

Attention deficit hyperactivity disorder in adolescent mania

Pages:271–273
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.271

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OBJECTIVE: The purpose of this study was to examine the rate of attention deficit hyperactivity disorder in adolescents with bipolar disorder and to explore the potential effects of comorbid attention deficit hyperactivity disorder on the phenomenology of ...

February 1995

REM sleep enhancement by bupropion in depressed men

Pages:274–276
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.274

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OBJECTIVE: The authors compared the effects of bupropion, fluoxetine, and cognitive behavior therapy on EEG sleep in depressed subjects. METHOD: All-night sleep EEG studies were performed before treatment and after partial or full remission on 18 men with ...

February 1995

Sodium lactate response and familial risk for panic disorder

Pages:277–279
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.277

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OBJECTIVE: The authors used the family study method to test the hypothesis that sodium lactate response defines two subtypes of panic disorder. METHOD: Rates of panic disorder in 142 first-degree relatives of patients who responded to sodium lactate, 88 ...

February 1995

Comorbidity of panic disorder in bipolar illness: evidence from the Epidemiologic Catchment Area Survey

Pages:280–282
Published Online:1 April 2006

https://doi.org/10.1176/ajp.152.2.280

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OBJECTIVE: The authors' goal was to determine the rate of comorbid panic disorder in individuals with bipolar disorder. METHOD: They used the Epidemiologic Catchment Area survey database to determine the prevalence of comorbid panic disorder in ...