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Psychiatry Online
Sections

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cover

American Journal of Psychiatry

Volume 175, Issue 12

December 2018
Cover: In this issue,Dr. Robert Freedman bids farewell as his Editorship concludes. The cover photo of Scripps Memorial Pier (La Jolla, Calif.) is courtesy of his longtime friend and first colleague in the field, Carlyle Chan, M.D., Professor of Psychiatry and the Institute for Health & Equity (Center for Bioethics & Medical Humanities), Medical College of Wisconsin, Milwaukee.
Editor’s Note
Audio
December 2018
A Farewell
  • Pages:1155–1156
  • Published Online:1 December 2018

https://doi.org/10.1176/appi.ajp.2018.18091108

Editorials
Introspection
Treatment in Psychiatry
Images in Psychiatry
December 2018
T.R. Beck (1791–1855)
  • Pages:1185–1186
  • Published Online:1 December 2018

https://doi.org/10.1176/appi.ajp.2018.18020176

Reviews and Overviews
December 2018
Improving Depression Outcome by Patient-Centered Medical Management
  • Pages:1187–1198
  • Published Online:17 September 2018

https://doi.org/10.1176/appi.ajp.2018.18040398

Preview Abstract
Specific challenges that profoundly affect the outcome of treatment for depression include 1) patient engagement and retention in care and optimization of treatment adherence, 2) optimization of symptom and side effect control by medication adjustments ...
December 2018
Integrating Health and Mental Health Services: A Past and Future History
  • Pages:1199–1204
  • Published Online:25 April 2018

https://doi.org/10.1176/appi.ajp.2018.18020169

Preview Abstract
The authors trace the modern history, current landscape, and future prospects for integration between mental health and general medical care in the United States. Research and new treatment models developed in the 1980s and early 1990s helped inform ...
Articles
Video
December 2018
Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism
  • Pages:1205–1215
  • Published Online:29 August 2018

https://doi.org/10.1176/appi.ajp.2018.18020138

Preview Abstract
Objective:In addition toN-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was to determine whether opioid receptor antagonism prior to administration of intravenous ketamine attenuates its ...
AudioCME
December 2018
Double-Blind Randomized Clinical Trial of Prazosin for Alcohol Use Disorder
  • Pages:1216–1224
  • Published Online:29 August 2018

https://doi.org/10.1176/appi.ajp.2018.17080913

Preview Abstract
Objective:Current medications for alcohol use disorder do not target brain noradrenergic pathways. Theoretical and preclinical evidence suggests that noradrenergic circuits may be involved in alcohol reinforcement and relapse. After a positive pilot study,...
December 2018
Risk of Major Malformations in Infants Following First-Trimester Exposure to Quetiapine
  • Pages:1225–1231
  • Published Online:16 August 2018

https://doi.org/10.1176/appi.ajp.2018.18010098

Preview Abstract
Objective:Second-generation antipsychotics are commonly prescribed to reproductive-age women for the treatment of a spectrum of psychiatric disorders. Quetiapine is the most commonly prescribed medication in this class, and therefore a better ...
AudioCME
December 2018
Intellectual Disability and Psychotic Disorders in Children: Association With Maternal Severe Mental Illness and Exposure to Obstetric Complications in a Whole-Population Cohort
  • Pages:1232–1242
  • Published Online:3 October 2018

https://doi.org/10.1176/appi.ajp.2018.17101153

Preview Abstract
Objective:Children of mothers with severe mental illness are at significantly increased risk of developing intellectual disability. Obstetric complications are also implicated in the risk for intellectual disability. Moreover, children of mothers with ...
Video
December 2018
Impaired Motion Processing in Schizophrenia and the Attenuated Psychosis Syndrome: Etiological and Clinical Implications
  • Pages:1243–1254
  • Published Online:3 October 2018

https://doi.org/10.1176/appi.ajp.2018.18010072

Preview Abstract
Objective:The ability to perceive the motion of biological objects, such as faces, is a critical component of daily function and correlates with the ability to successfully navigate social situations (social cognition). Deficits in motion perception in ...
December 2018
Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression
  • Pages:1255–1264
  • Published Online:16 August 2018

https://doi.org/10.1176/appi.ajp.2018.17070825

Preview Abstract
Objective:White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is ...
Letters to the Editor
Book Forum
Appreciation
Issue Highlights
Tweets by @AmJPsychiatry
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