Objective:Morbidly obese patients frequently present with mood and anxiety disorders, which are often treated with serotonin reuptake inhibitors (SRIs). Having observed that patients treated with SRIs frequently relapse after Roux-en-Y gastric bypass ...

Reviews and Overviews

March 2012

Striatal Dopamine Transporter Alterations in ADHD: Pathophysiology or Adaptation to Psychostimulants? A Meta-Analysis

Pages:264–272
Published Online:1 March 2012

https://doi.org/10.1176/appi.ajp.2011.11060940

Preview Abstract

Background:Striatal dopamine transporter abnormalities are thought to underlie the pathophysiology and psychostimulant treatment of attention deficit hyperactivity disorder (ADHD). However, individual studies using single photon emission tomography (SPECT)...

Articles

March 2012

An Empirically Derived Taxonomy for Personality Diagnosis: Bridging Science and Practice in Conceptualizing Personality

Pages:273–284
Published Online:1 March 2012

https://doi.org/10.1176/appi.ajp.2011.11020274

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Objective:The authors describe a system for diagnosing personality pathology that is empirically derived, clinically relevant, and practical for day-to-day use. Method:A random national sample of psychiatrists and clinical psychologists (N=1,201) ...

March 2012

Antiepileptic Drugs for Bipolar Disorder and the Risk of Suicidal Behavior: A 30-Year Observational Study

Pages:285–291
Published Online:1 March 2012

https://doi.org/10.1176/appi.ajp.2011.11060948

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The FDA in 2009 warned of increased suicidality with all antiepileptic drugs, regardless of the illness being treated. Longitudinal clinical observations of 199 bipolar patients taking carbamazepine, lamotrigine, or valproate in five U.S. medical centers ...

March 2012

A Double-Blind Placebo-Controlled Trial of Fluoxetine for Repetitive Behaviors and Global Severity in Adult Autism Spectrum Disorders

Pages:292–299
Published Online:1 March 2012

https://doi.org/10.1176/appi.ajp.2011.10050764

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Objective:The effects of fluoxetine and placebo on repetitive behaviors and global severity were compared in adults with autism spectrum disorders (ASDs). Method:Adults with ASDs were enrolled in a 12-week double-blind placebo-controlled fluoxetine trial. ...

March 2012

Association of Cerebral Emboli With Accelerated Cognitive Deterioration in Alzheimer's Disease and Vascular Dementia

Nitin Purandare,Ph.D., F.R.C.Psych.,
Alistair Burns,M.D., F.R.C.Psych.,
Julie Morris,M.Sc.,
Ewan P. Perry,Ph.D.,
Joanne Wren,B.Sc., and
Charles McCollum,M.D., F.R.C.S.

Pages:300–308
Published Online:1 March 2012

https://doi.org/10.1176/appi.ajp.2011.11010009

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Transcranial Doppler imaging found middle cerebral artery emboli in nearly half of patients with either vascular or Alzheimer's dementia. Patients with emboli had more rapid progression of dementia over 2 years than those who were emboli free, and their ...

March 2012

The Interaction of Parental History of Suicidal Behavior and Exposure to Adoptive Parents' Psychiatric Disorders on Adoptee Suicide Attempt Hospitalizations

Holly C. Wilcox,Ph.D.,
S. Janet Kuramoto,Ph.D., M.H.S.,
David Brent,M.D., and
Bo Runeson,M.D., Ph.D.

Pages:309–315
Published Online:1 March 2012

https://doi.org/10.1176/appi.ajp.2011.11060890

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Objective:The authors examined the risk of suicide attempt or other psychiatric hospitalization among adoptees whose biological parents died from or were hospitalized for suicidal behavior (BPSB) relative to adoptees whose biological parents had a ...

March 2012

Increased Medial Orbitofrontal and Amygdala Activation: Evidence for a Systems-Level Endophenotype of Bipolar I Disorder

Julia Linke,M.S.,
Andrea Victoria King,M.S.,
Marcella Rietschel,M.D.,
Jana Strohmaier,M.S.,
Michael Hennerici,M.D.,
Achim Gass,M.D.,
Andreas Meyer-Lindenberg,M.D., Ph.D., and
Michèle Wessa,Ph.D.

Pages:316–325
Published Online:1 March 2012

https://doi.org/10.1176/appi.ajp.2011.11050711

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Objective:Bipolar I disorder is highly heritable, but endophenotypes of the disorder mediating genetic risk are only beginning to be defined. The authors investigate state- and trait-related neural mechanisms related to motivation in euthymic bipolar ...

March 2012

Lower β₂*-Nicotinic Acetylcholine Receptor Availability in Smokers With Schizophrenia

Pages:326–334
Published Online:1 March 2012

https://doi.org/10.1176/appi.ajp.2011.11020189

Preview Abstract

Objective:There is a strong association between cigarette smoking and schizophrenia. Nicotine's actions in the brain are mediated through nicotinic acetylcholine receptors. Those containing α₄ and β₂ subunits are the most abundant ones in the brain, have ...