Objective:How long clinicians should wait before considering an antipsychotic ineffective and changing treatment in schizophrenia is an unresolved clinical question. Guidelines differ substantially in this regard. The authors conducted a diagnostic test ...

Articles

July 2015

The Intergenerational Transmission of Anxiety: A Children-of-Twins Study

Pages:630–637
Published Online:23 April 2015

https://doi.org/10.1176/appi.ajp.2015.14070818

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Objective:The transmission of anxiety within families is well recognized, but the underlying processes are poorly understood. Twin studies of adolescent anxiety demonstrate both genetic and environmental influence, and multiple aspects of parenting are ...

July 2015

Diagnostic Precursors to Bipolar Disorder in Offspring of Parents With Bipolar Disorder: A Longitudinal Study

David Axelson,M.D.,
Benjamin Goldstein,M.D., Ph.D.,
Tina Goldstein,Ph.D.,
Kelly Monk,R.N.,
Haifeng Yu,M.S.,
Mary Beth Hickey,B.A.,
Dara Sakolsky,M.D., Ph.D.,
Rasim Diler,M.D.,
Danella Hafeman,M.D., Ph.D.,
John Merranko,M.A.,
Satish Iyengar,Ph.D.,
David Brent,M.D., M.P.H.,
David Kupfer,M.D.,
Boris Birmaher,M.D.

Pages:638–646
Published Online:3 March 2015

https://doi.org/10.1176/appi.ajp.2014.14010035

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Objective:The authors sought to identify diagnostic risk factors of manic, mixed, or hypomanic episodes in the offspring of parents with bipolar disorder (“high-risk offspring”).Method:High-risk offspring 6–18 years old (N=391) and demographically matched ...

July 2015

Pediatric-Onset and Adult-Onset Separation Anxiety Disorder Across Countries in the World Mental Health Survey

Derrick Silove,M.D., Ph.D.,
Jordi Alonso,M.D., Ph.D.,
Evelyn Bromet,Ph.D.,
Mike Gruber,M.S.,
Nancy Sampson,B.A.,
Kate Scott,Ph.D.,
Laura Andrade,M.D., Ph.D.,
Corina Benjet,Ph.D.,
Jose Miguel Caldas de Almeida,M.D., Ph.D.,
Giovanni De Girolamo,M.D.,
Peter de Jonge,Ph.D.,
Koen Demyttenaere,M.D., Ph.D.,
Fabian Fiestas,M.D.,
Silvia Florescu,M.D., Ph.D.,.
Oye Gureje,Ph.D.,
Yanling He,M.D.,
Elie Karam,M.D.,
Jean-Pierre Lepine,Ph.D.,
Sam Murphy,Ph.D.,
Jose Villa-Posada,M.D.,
Zahari Zarkov,M.D.,
Ronald C. Kessler,Ph.D.

Pages:647–656
Published Online:5 June 2015

https://doi.org/10.1176/appi.ajp.2015.14091185

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Objective:The age-at-onset criterion for separation anxiety disorder was removed in DSM-5, making it timely to examine the epidemiology of separation anxiety disorder as a disorder with onsets spanning the life course, using cross-country data.Method:The ...

July 2015

Longitudinal Stability of Genetic and Environmental Influences on Irritability: From Childhood to Young Adulthood

Pages:657–664
Published Online:23 April 2015

https://doi.org/10.1176/appi.ajp.2015.14040509

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Objective:Little is known about genetic influences on juvenile irritability and whether such influences are developmentally stable and/or dynamic. This study examined the temporal pattern of genetic and environmental effects on irritability using data ...

July 2015

Overactive Performance Monitoring as an Endophenotype for Obsessive-Compulsive Disorder: Evidence From a Treatment Study

Pages:665–673
Published Online:17 March 2015

https://doi.org/10.1176/appi.ajp.2014.14070886

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Objective:Overactive performance monitoring, as measured by the error-related negativity in the event-related brain potential, represents one of the most robust psychophysiological alterations in obsessive-compulsive disorder (OCD). It has been proposed ...

July 2015

Distinguishing Adolescents With ADHD From Their Unaffected Siblings and Healthy Comparison Subjects by Neural Activation Patterns During Response Inhibition

Pages:674–683
Published Online:23 January 2015

https://doi.org/10.1176/appi.ajp.2014.13121635

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Objective:Dysfunctional response inhibition is a key executive function impairment in attention deficit hyperactivity disorder (ADHD). Still, behavioral response inhibition measures do not consistently differentiate affected from unaffected individuals. ...