OBJECTIVE: The study of social cognition in schizophrenia has received growing attention in recent years. At the same time, a large body of work has explored the neural basis of social cognition in both nonclinical and clinical groups, other than those ...

May 2003

Cognitive Behavior Therapy for Depression? Choose Horses for Courses

Gordon Parker,D.Sc., M.D., Ph.D., F.R.A.N.Z.C.P.,
Kay Roy,B.A., and
Kerrie Eyers,M.A., M.P.H., M.A.P.S.

Pages:825–834
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.825

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OBJECTIVE: Although cognitive behavior therapy is a widely accepted treatment for depression, the problematic nature of efficacy studies is insufficiently recognized. METHOD: The authors reviewed original studies and quantitative analyses on the use of ...

May 2003

Transcranial Magnetic Stimulation in the Treatment of Depression

Pages:835–845
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.835

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OBJECTIVE: Transcranial magnetic stimulation (TMS) is a noninvasive and easily tolerated method of altering cortical physiology. The authors evaluate evidence from the last decade supporting a possible role for TMS in the treatment of depression and ...

Images in Neuroscience

May 2003

Schizophrenia, I

Carol A. Tamminga,M.D.

Page:846
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.846

Introspections

May 2003

Scaling Down

Mary V. Seeman,M.D.

Pages:847–849
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.847

Clinical Case Conference

May 2003

An Impaired Physician With Complex Comorbidity

Pages:850–854
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.850

Images in Psychiatry

May 2003

Dalí (1904–1989): Psychoanalysis and Pictorial Surrealism

Pages:855–856
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.855

Article

May 2003

A Collaborative Study of the Emergence and Clinical Features of the Major Depressive Syndrome of Alzheimer’s Disease

Pages:857–866
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.857

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OBJECTIVE: This report provides a description of the prevalence and clinical features of the major depressive syndrome of Alzheimer’s disease using data derived from structured diagnostic assessments of 243 patients with probable Alzheimer’s disease and ...

May 2003

Amyloid β Pathology in Alzheimer’s Disease and Schizophrenia

Pages:867–872
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.867

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OBJECTIVE: Severe cognitive impairment is common in elderly patients with schizophrenia. Alzheimer’s disease is the main cause of dementia among the elderly. Biochemical and genetic studies suggest that amyloid β-peptide is central in Alzheimer’s disease. ...

May 2003

Lower Concentration of HippocampalN-Acetylaspartate in Familial Bipolar I Disorder

Pages:873–882
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.873

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OBJECTIVE: Previous studies attempting to identify neuropathological alterations in the hippocampus in bipolar disorder have been inconclusive. The objective of this study was to determine if the concentration ofN-acetylaspartate, a neuronal and axonal ...

May 2003

Gender Differences in Prevalence, Risk, and Clinical Correlates of Alcoholism Comorbidity in Bipolar Disorder

Pages:883–889
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.883

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OBJECTIVE: The prevalence of lifetime alcohol abuse and/or dependence (alcoholism) in patients with bipolar disorder has been reported to be higher than in all other axis I psychiatric diagnoses. This study examined gender-specific relationships between ...

May 2003

The Role of Psychiatric Disorders in Predicting Drug Dependence Treatment Outcomes

Pages:890–895
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.890

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OBJECTIVE: Previous research has demonstrated that psychiatric disorders are common among people who abuse alcohol and drugs, but few studies have examined the relationship of psychiatric disorders to drug treatment outcome. The authors conducted such an ...

May 2003

Decreased Striatal Dopamine D₁ Receptor- Stimulated Adenylyl Cyclase Activity in Human Methamphetamine Users

Pages:896–903
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.896

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OBJECTIVE: It has been assumed that some behavioral changes associated with repeated exposure to dopaminergic psychostimulant drugs might be explained by changes in activity of dopamine receptors, including the dopamine D₁ receptor, which is linked by a ...

May 2003

Personality Traits and Striatal Dopamine Synthesis Capacity in Healthy Subjects

Aki Laakso,M.D., Ph.D.,
Esa Wallius,M.Sc.,
Jaana Kajander,M.D.,
Jörgen Bergman,M.Sc.,
Olli Eskola,M.Sc.,
Olof Solin,Ph.D.,
Tuula Ilonen,Ph.D.,
Raimo K.R. Salokangas,M.D., Ph.D.,
Erkka Syvälahti,M.D., Ph.D., and
Jarmo Hietala,M.D., Ph.D.

Pages:904–910
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.904

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OBJECTIVE: Neuroimaging and genetic studies suggest that individual differences in the brain dopaminergic system contribute to the normal variability of human personality (e.g., social detachment and novelty seeking). The authors studied whether ...

May 2003

An fMRI Study of Episodic Encoding and Recognition of Words in Patients With Schizophrenia in Remission

Pages:911–918
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.911

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OBJECTIVE: Verbal memory deficits are among the most severe cognitive deficits observed in patients with schizophrenia. This study examined patterns of brain activity during episodic encoding and recognition of words in patients with schizophrenia. METHOD:...

May 2003

Functional Disconnection Between the Prefrontal and Parietal Cortices During Working Memory Processing in Schizophrenia: A [¹⁵O]H₂O PET Study

Jae-Jin Kim,M.D., Ph.D.,
Jun Soo Kwon,M.D., Ph.D.,
Hae Jeong Park,Ph.D.,
Tak Youn,M.D.,
Do Hyung Kang,M.D.,
Myung Sun Kim,Ph.D.,
Dong Soo Lee,M.D., Ph.D., and
Myung Chul Lee,M.D., Ph.D.

Pages:919–923
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.919

Preview Abstract

OBJECTIVE: The prefrontal-parietal circuits have been reported to play an important role in working memory. The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is ...

May 2003

MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder

Pages:924–932
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.924

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OBJECTIVE: Animal studies have suggested that early stress is associated with alterations in the hippocampus, a brain area that plays a critical role in learning and memory. The purpose of this study was to measure both hippocampal structure and function ...

May 2003

The Relationship Between Childhood Physical Abuse and Suicidality Among Depressed Women: Results From a Community Sample

Pages:933–938
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.933

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OBJECTIVE: The aim of this study was to examine the distribution and determinants of suicidal ideation and suicide attempts in a community sample of women with major depressive disorder. Variables of interest included childhood physical abuse, individual ...

May 2003

Family Disruption in Childhood and Risk of Adult Depression

Pages:939–946
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.939

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OBJECTIVE: The authors examined the risk that family disruption and low socioeconomic status in early childhood confer on the onset of major depression in adulthood. METHOD: Participants were 1,104 offspring of mothers enrolled during pregnancy in the ...

May 2003

Risk of Repeat Offending Among Violent Female Offenders With Psychotic and Personality Disorders

Hanna Putkonen,M.D.,
Erkki J. Komulainen,Ph.D.,
Matti Virkkunen,M.D., Ph.D.,
Markku Eronen,M.D., Ph.D., and
Jouko Lönnqvist,M.D., Ph.D.

Pages:947–951
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.947

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OBJECTIVE: The aim of this study was to examine the rate of criminal recidivism among female homicide offenders evaluated by forensic psychiatrists, to compare this rate with that of other violent female offenders, and to analyze the explanatory variables ...

May 2003

Personality Diagnoses in Adolescence: DSM-IV Axis II Diagnoses and an Empirically Derived Alternative

Pages:952–966
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.952

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OBJECTIVE: The study of personality pathology in adolescence is in its infancy. This article examined the applicability and limits of DSM-IV axis II personality disorder diagnoses in adolescents, assessed the validity of a method for assessing adolescent ...

May 2003

The Intermediate-Term Outcome of Chinese Patients With Anorexia Nervosa in Hong Kong

Sing Lee,F.R.C.Psych.,
Y.Y. Lydia Chan,M.A., and
L.K. George Hsu,M.D.

Pages:967–972
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.967

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OBJECTIVE: The authors determined the intermediate-term outcome of anorexia nervosa for Chinese patients in Hong Kong. METHOD: A consecutive series of 88 patients who fulfilled DSM-III-R criteria for typical (i.e., fat phobic [N=63]) and atypical (i.e., ...

May 2003

Self-Help for Bulimia Nervosa: A Randomized Controlled Trial

Pages:973–978
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.973

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OBJECTIVE: The authors examined the effectiveness of unguided self-help as a first step in the treatment of bulimia nervosa. METHOD: A total of 85 women with bulimia nervosa who were on a waiting list for treatment at a hospital-based clinic participated. ...

May 2003

Youth Hate Crimes: Identification, Prevention, and Intervention

Pages:979–989
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.979

Preview Abstract

OBJECTIVE: Youth hate crimes are a societal problem in which young people turn extremist ideas into acts of violence. To develop methods for prevention, early identification, and intervention, mental health professionals must have an awareness and ...

Brief Report

May 2003

Toward a Neuropsychological Theory of Antidepressant Drug Action: Increase in Positive Emotional Bias After Potentiation of Norepinephrine Activity

Catherine J. Harmer,D.Phil.,
Simon A. Hill,M.R.C.Psych.,
Matthew J. Taylor,M.R.C.Psych.,
Philip J. Cowen,M.D., F.R.C.Psych., and
Guy M. Goodwin,D.Phil., F.R.C.Psych.

Pages:990–992
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.990

Preview Abstract

OBJECTIVE: Antidepressants that increase serotonin or norepinephrine in the brain are effective in treating depression, but there is no neuropsychological account of how these changes relieve depressive states. Cognitive theories suggest that biases in ...

May 2003

Placental Passage of Antidepressant Medications

Pages:993–996
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.993

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OBJECTIVE: This study determined the placental transfer of antidepressants and their metabolites. METHOD: A total of 38 pregnant women taking citalopram, fluoxetine, paroxetine, or sertraline participated. Maternal and umbilical cord blood samples were ...

May 2003

A Double-Blind, Placebo-Controlled Study of the Omega-3 Fatty Acid Docosahexaenoic Acid in the Treatment of Major Depression

Pages:996–998
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.996

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OBJECTIVE: This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression. METHOD: Thirty-six depressed patients were randomly assigned to receive DHA, 2 g/day, or placebo for 6 weeks. Response was ...

May 2003

Age at Onset in Bipolar I Affective Disorder: Further Evidence for Three Subgroups

Frank Bellivier,M.D., Ph.D.,
Jean-Louis Golmard,M.D., Ph.D.,
Marcella Rietschel,M.D., Ph.D.,
Thomas G. Schulze,M.D.,
Alain Malafosse,M.D., Ph.D.,
Martin Preisig,M.D., M.P.H.,
Patrick McKeon,M.D., Ph.D.,
Lesley Mynett-Johnson,M.D., Ph.D.,
Chantal Henry,M.D., Ph.D., and
Marion Leboyer,M.D., Ph.D.

Pages:999–1001
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.999

Preview Abstract

OBJECTIVE: Preliminary data suggested that there are three subgroups of bipolar affective disorder based on age at onset. The authors sought to replicate those findings and determine the cut-off age of each subgroup. METHOD: Admixture analysis was used to ...

May 2003

Obsessive-Compulsive Disorder in Adolescent Schizophrenia Patients

Pages:1002–1004
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.1002

Preview Abstract

OBJECTIVE: The co-occurrence of obsessive-compulsive disorder (OCD) in adult patients with schizophrenia has been increasingly recognized. However, the rate of OCD comorbidity in adolescent schizophrenia patients has yet to be systematically evaluated. ...

May 2003

Pathways of Low-Income Minority Patients to Outpatient Psychiatric Treatment

Heidi Boerstler,Dr.P.H., J.D., and
John M. de Figueiredo,M.D., Sc.D.

Pages:1004–1007
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.1004

Preview Abstract

OBJECTIVE: Low-income outpatients with scheduled appointments (“scheduled patients”) were compared with those who sought treatment without appointments (“walk-ins”). METHOD: The charts of scheduled patients and walk-ins at an outpatient mental health ...

May 2003

Comorbidity of Severe Psychiatric Disorders and Substance Use Disorders Among Women in Jail

Pages:1007–1010
Published Online:1 May 2003

https://doi.org/10.1176/appi.ajp.160.5.1007

Preview Abstract

OBJECTIVE: This article presents the prevalence, patterns, and sequences of severe psychiatric disorders and substance use disorders among female jail detainees. METHOD: Subjects were a randomly selected, stratified sample of 1,272 female arrestees ...