Our research is built upon our Faculty of almost 40 research leaders. Each develops his or her own hypothesis-driven research, seeking answers to important biomedical questions. The Faculty member leads a team of postdoctoral fellows, PhD students and support staff.
The research projects of each Faculty member must strengthen our overarching areas of Human Genetics, Mouse and Zebrafish Genetics, Pathogen Genetics, Malaria, and Bioinformatics.
Faculty members often lead national or international collaborative programmes. In addition, most are responsible for one or more of our main resources, such as sequencing programmes or database development.
David uses DNA sequencing of patients and genetic screens in human cells and mice to identify cancer genes and genetic interactions.
David'semail,profile andproject
Carl applies statistical methodology to the analysis of large-scale genetic data sets in a bid to better understand the causes of several common human diseases.
Carl'semail,profile andproject
Jeffrey develops and applies statistical and computational methods for elucidating the genetic factors in complex human diseases, especially those involving autoimmunity.
Jeffrey'semail,profile andproject
Inês is Head of Human Genetics and represents Human Genetics on the Board of Management. Inês established the Sanger Institute's Metabolic Disease Group, which uses genetic and genomic approaches to understand the aetiology of common and rare forms of metabolic disease.
Inês'email,profile andproject
Matt leads a programme in the genomics of neglected tropical disease parasites, including helminths such as schistosomes, tapeworms, roundworms, hookworms, threadworms and whipworms. He also works closely with the Malaria programme.
Matt'semail,profile andproject
Oliver uses experimental genetics in rodent models to study the basic biology of malaria parasites and their interactions with host and mosquito vectors.
Oliver'semail,profile andproject
Allan Bradley leads the Sanger Institute's Mouse Genomics Team, which uses the mouse as a model system to investigate the function of individual genes. He is former Director of the Institute, where he holds the title of Director Emeritus.
Allan'semail,profile andproject
Dr Peter Campbell is Head of the Sanger Institute's Cancer Genome Project. His research focuses on the use of next-generation sequencing technologies for annotating cancer genomes.
Peter'semail,profile andproject
Gordon leads the Microbial pathogenesis group, which investigates the relationship between pathogens and hosts.
Gordon'semail,profile andproject
Richard is Acting Head of Computational Genomics at the Wellcome Trust Sanger Institute. Richard has worked on many areas of biological sequence analysis, and currently focuses on studying human genetic variation by genome-wide resequencing using new sequencing technologies.
Richard'semail,profile andproject
Daniel's group combines computational and statistical methods with high-throughput experimental techniques to understand the role played by changes in gene regulation in disease susceptibility and human evolution.
Daniel'semail,profile andproject
Mathew investigates how genetic alterations in cancer contribute to disease and impact on response to therapy.
Mathew'semail andprofile andproject
Martin develops computer models of gene regulation, with a focus on gene activity levels in single cells and the genomic regions involved.
Martin'semail andprofile.
Matt's group aims to elucidate the genetic architecture of developmental disorders, and characterise mutation processes in mammalian genomes.
Matthew'semail,profile andproject
Paul's laboratory investigates virus genetic variation and virus-host cell interactions. He is a Professor of Viral Pathogenesis at University College London.
Paul'semail,profile andproject
Dominic is Head of the Malaria Programme at the Sanger Institute, which uses genomic and genetic approaches to study natural genetic variation in Plasmodium parasites and Anopheles vectors, as well as human genetic determinants of severe malaria.
Dominic'semail,profile andproject
Trevor studies the mechanisms that underlie how micro-organisms in the gut interact with their host during periods of health and disease. In particular he seeks to develop novel ways to treat diseases that are associated with unwanted imbalances in the micro-organism population.
Trevor'semail,profile andproject
Mara studies how genetic variation in mosquitoes influences the development of the human malaria parasites they carry
Mara'semail,profile andproject
Pentao's laboratory studies cancer and mouse development. He uses a range of genetic, genomic and biochemical approaches in the lab and develops novel technologies to facilitate the lab's studies.
Pentao'semail,profile andproject
Darren's team aims to understand the genes that enable animals to detect and respond to social signals with an appropriate behaviour
Darren'semail,profile andproject
Ultan's goal is to integrate genomic and drug sensitivity datasets from human cancer cell line models in order to identify biomarkers to use in clinical trials.
Ultan'semail,profile andproject pages.
Ville develops computational methods to discover and understand functionally relevant genetic and phenotypic variation.
Ville'semail,profile andproject pages.
Julian is the Board of Management representative for the Pathogen Variation Programme at the Sanger Institute.. He uses high-throughput sequencing and phenotyping to study pathogen diversity and variation, how they affect virulence and transmission, and what they tell us about the evolution of pathogenicity and host interactions.
Julian'semail,profile andproject
Julian's lab investigates the molecular details of human-parasite interactions during theP. falciparum blood stages, with a particular focus on genomic and proteomic approaches to understanding erythrocyte invasion and how that process is influenced by natural genetic variation in both host and parasite.
Julian'semail,profile andproject
Manj's research explores genomic diversity and its impact on infectious and cardiometabolic risk factors among populations.
Manj'semail,profile andproject
Bill is exploiting new genome-editing technology for the study of gene function and disease modelling in human stem cells.
Bill'semail,profile andproject
Nicole's team works to expand discovery of novel genetic loci for intermediate cardiovascular endpoints through associations of common and rare DNA variation with biochemical and physiologic intermediate phenotypes.
Nicole'semail,profile andproject
Derek is Head of Mouse and Zebrafish Genetics. Derek's team works on a range of projects related to growth and development and human disease, using the model organismsX. tropicalis and the zebrafish.
Derek'semail,profile andproject
Mike Stratton is Director of the Wellcome Trust Sanger Institute, where he initiated the Cancer Genome Project, which conducts systematic genome-wide searches for somatic mutations in human cancer.
Michael'semail,profile andproject
Sarah's group uses genomic approaches to study global regulation of gene expression in the mouse immune system.
Sarah'semail,profile andproject
Nick investigates bacterial evolution and spread with a focus on sexually transmitted and diarrhoeal diseases. He is also Professor of Bacterial Genomics and Evolution at the London School of Hygiene and Tropical Medicine.
Nick'semail,profile andproject
Gosia's team studies how genetic variants influence many aspects of the immune system and predispose to autoimmune diseases.
Gosia'semail andprofile
Chris investigates the genetic variation in human populations and the insights this provides into human evolution.
Chris'email,profile andproject
Ludovic's group identifies RNA signalling and regulation networks and the genetic variants that control pancreas development to explore their involvement in metabolic disorders.
Ludovic'semail andprofile andproject
George's research seeks to understand the genetic pathways involved in the pathogenesis of haematological cancers and help develop targeted anti-leukaemic therapies.
George'semail andprofile andproject
Gavin's research focuses on taking large-scale systematic approaches to identify novel receptor-ligand pairs that initiate intercellular signalling.
Gavin'semail,profile andproject
Vijay's laboratory uses mouse genetic, genomic, and proteomic approaches to investigate how molecules originating from within, and outside the bone regulate bone remodelling.
Vijay'semail,profile andproject
Associate Faculty members spend part of their time at the Institute, bringing complementary insights and expertise of new areas of research to the knowledge and resources of the Sanger Institute and thus broaden our portfolio of scientific inquiry.
Adrian's group studies the way chemical marking of chromosomes affects the activity of the genome in normal and diseased cells.
Adrian'semail,profile andproject
Ewan's group is using genomic data to study changes in skeleton shape and form, the development of heart problems, and basic biological processes in human in whole organisms and individual cells.
Ewan'semail,profile andproject
John will be working with the Institute to further understand cardiometabolic traits through combining cardiovascular epidemiology with genomic research techniques.
John'semail.
Bob's research group is involved in the development of novel treatments for antibiotic resistant infections.
Bob'semail,profile andproject
Steve's group focuses on understanding how cells detect and repair DNA damage.
Steve'semail,profile andproject
John develops computational and statistical tools to exploit high-throughput genomics data to understand the regulation of gene expression and to model developmental and evolutionary processes.
John'semail andprofile
Eric Miska is the Herchel Smith Professor of Molecular Genetics at the University of Cambridge. Eric has strong and diverse interests in genomic biology, including in small RNA biology, epigenetic chromatin regulation and molecular evolution. He has joined the Computational Genomics Programme and will also be working closely with the Mouse and Zebrafish, Human Genetics and Cellular Genetics Programmes.
Eric'sprofile.
Duncan Odom's research group compares how transcription and transcriptional regulation vary during evolution, and the implications this regulatory plasticity has for diseases such as cancer.
Duncan'shome institute email,Sanger Institute email,profile andproject
Chris' group analyses next-generation sequencing data to better understand basic biological and disease processes.
Chris'email,profile andproject
Fiona will work with the Institute towards further understanding of intestinal microbiota host interactions and of how these influence infectious and chronic inflammatory diseases.
Fiona'semail
Stephen will be working with the Institute towards further understanding the molecular mechanisms in metabolic disease.
Stephen'semail
Wolf's team investigates the way additional information can be added to DNA sequence in the genome through a process called epigenetics.
Wolf'semail,profile andproject
Toni will be working with the Institute using mouse models to understand genes that affect energy balance and mechanisms responsible for the secondary complications of obesity.
Toni'semail
Thierry's group focuses on developing methods that characterise the DNA and RNA in a single cell to enable the exploration of DNA-mutation, the genetic differences between cells in a person's body and the relation of this diversity to disease.
Thierry'semail,profile andproject
The Sanger Institute has an Honorary Faculty of researchers from other research centres. Our Honorary Faculty collaborate closely with teams at the Sanger Institute to answer a range of research questions.
Previous members of our Faculty have developed their research in other centres around the globe. Access information and email addresses for previous Faculty.
